Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)
| General Information of HIF (ID: HIFM0212) | |||||
|---|---|---|---|---|---|
| HIF Name |
Protransforming growth factor alpha
|
||||
| HIF Synonym(s) |
LOC100136774, transforming growth factor beta-1-like, tgf, tgfb1, TGF-beta, TGF-beta1a
|
||||
| HIF Classification |
Cytokine (Cyt)
|
||||
| Molecular Function |
Growth factor; Mitogen
|
||||
| Description | TGF is a ligand for EGFR and activates the EGFR signaling pathway promoting tumor progression by triggering downstream signaling molecules like AKT and MAPK. | [1] | |||
| Pathway | Colorectal cancer (hsa05210 ) | ||||
| EGFR tyrosine kinase inhibitor resistance (hsa01521 ) | |||||
| ErbB signaling pathway (hsa04012 ) | |||||
| Estrogen signaling pathway (hsa04915 ) | |||||
| Glioma (hsa05214 ) | |||||
| Hepatocellular carcinoma (hsa05225 ) | |||||
| MAPK signaling pathway (hsa04010 ) | |||||
| Non-small cell lung cancer (hsa05223 ) | |||||
| PI3K-Akt signaling pathway (hsa04151 ) | |||||
| Pancreatic cancer (hsa05212 ) | |||||
| Pathways in cancer (hsa05200 ) | |||||
| Prostate cancer (hsa05215 ) | |||||
| Ras signaling pathway (hsa04014 ) | |||||
| Renal cell carcinoma (hsa05211 ) | |||||
| Sequence | Click here to download the HIF sequence in FASTA format | ||||
| External Links | |||||
| Uniprot ID | |||||
| Microbe Species (MIC) Regulated by This HIF | |||||
|---|---|---|---|---|---|
| Yersinia pestis (enterobacteria) | MIC01401 | ||||
| Description | Yersinia pestis causes apoptosis and poptotic cells are cleared by phagocytes to trigger production of the anti-infl ammatory cytokines TGFalpa. | [2] | |||
If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.