General Information of MIC (ID: MIC00417)
MIC Name	Paeniclostridium sordellii (firmicutes)
MIC Synonyms	Clostridium sordellii
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Peptostreptococcaceae Genus: Paeniclostridium Species: Paeniclostridium sordellii
Oxygen Sensitivity	Anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Positive
Host Relationship	Pathogen
Description	Paeniclostridium sordellii is a rare anaerobic, Gram-positive, spore-forming rod with peritrichous flagella that is capable of causing pneumonia, endocarditis, arthritis, peritonitis and myonecrosis.
External Links	Taxonomy ID	1505
	Genome Assembly ID	ASM44407v1
	GOLD Organism ID	Go0502533

Host Immune Factors (HIFs)
Interferon-10
HIF ID	HIFM0128	HIF Info	Class	Cytokine (Cyt)
Description	Stimulation of mononuclear cells with Clostridium sordellii induced production of the immunoregulatory cytokine IL-10 (50.614.03 ng/ml).				[1]
Tumor necrosis factor
HIF ID	HIFM0226	HIF Info	Class	Cytokine (Cyt)
Description	Isolated human monocytes produced the pro-inflammatory cytokine TNFalpha and the immunoregulator IL-10 in response to Clostridium sordellii.				[1]
Toll-like receptor 2
HIF ID	HIFM0217	HIF Info	Class	Toll-like receptor (TLR)
Description	Clostridium sordellii was nearly 2-fold higher well recognized when TLR2 was co-expressed with TLR6 than expressing TLR2 alone.				[1]
Toll-like receptor 6
HIF ID	HIFM0221	HIF Info	Class	Toll-like receptor (TLR)
Description	Innate immune recognition of, and response to, cell-associated components of C. sordellii and other clostridial pathogens are mediated by TLR2 in combination with TLR6.				[1]

Environmental Factor(s)
Disbiome ID			204

References
1	Innate immune recognition of, and response to, Clostridium sordellii. Anaerobe. 2010 Apr;16(2):125-30. doi: 10.1016/j.anaerobe.2009.06.004. Epub 2009 Jun 25.

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