General Information of HIF (ID: HIFM0202)
HIF Name	Ribonuclease 8
HIF Synonym(s)	Rnase 8, RNase 8
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Endonuclease; Hydrolase; Nuclease
Description	RNase 8 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Pancreatic ribonuclease (PF00074 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	RNAS8_HUMAN
	APD ID	AP02101

Microbe Species (MIC) Regulated by This HIF
Candida albicans (budding yeasts)			MIC00317
Description	RNase 8 had antimicrobial activity against Candida albicans.				[2]
Candida glabrata (budding yeasts)			MIC01794
Description	RNase 8 had significant antimicrobial activity against Candida glabrata(p<0.0001).				[2]
Pseudomonas aeruginosa (gamma-proteobacteria)			MIC01054
Description	RNase 8 had no significant antimicrobial activity against Pseudomonas aeruginosa(p>0.05)at the cefotaxime (30 g), ceftazidime (30 g), cefoperazone (75 g),and ceftriaxone (30 g) on MH agar.				[2]
Staphylococcus aureus (firmicutes)			MIC01208
Description	RNase 8 had significant antimicrobial activity against Staphylococcus aureus(p<0.0001).				[2]
Streptococcus thermophilus (firmicutes)			MIC01272
Description	RNase 8 had significant antimicrobial activity against Streptococcus thermophilus(p<0.0001).				[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	RNase 1, 2, 5 & 8 role in innate immunity: Strain specific antimicrobial activity.Int J Biol Macromol. 2020 Jun 3;160:1042-1049. doi: 10.1016/j.ijbiomac.2020.06.001. Online ahead of print.

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