Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFC0028)
HIF Name
Natural Killer cells
HIF Synonym(s)
Natural killer (NK) T-like cells, Natural Killer Cells
HIF Classification
Natural killer cells (NKCs)
Description Natural killer cells (also known as NK cells, K cells, and killer cells) are a type of lymphocyte (a white blood cell) and a component of innate immune system. [1]
Microbe Species (MIC) Regulated by This HIF
         Chlamydia felis (chlamydias) MIC00349
             Description Natural killer cells were an important source of IFN-gamma in the early innate immune response to Chlamydia felis infection. [2]
         Ehrlichia chaffeensis (alpha-proteobacteria) MIC00523
             Description Ehrlichia chaffeensis lipoproteins may be able to activate NK cells. [3]
         Lachnospiraceae (firmicutes) MIC00695
             Description Relative abundances of Lachnospiraceae was associated with Natural killer (NK) T-like cells. [4]
         Lactobacillus paracasei (firmicutes) MIC00726
             Description Lactobacillus paracasei could increase the level of NK cells. [5]
         Listeria monocytogenes (firmicutes) MIC00771
             Description Listeria monocytogenes is associated with NK cell responses. [6]
         Streptococcus thermophilus (firmicutes) MIC01272
             Description NK cells secreted colony-stimulating factor (CSF)-2 which was significantly increased after co-culturing peripheral blood mononuclear cell with Streptococcus thermophilus bacteria. [7]
References
1 Protective role of NKT cells and macrophage M2-driven phenotype in bleomycin-induced pulmonary fibrosis.Inflammopharmacology. 2018 Apr;26(2):491-504. doi: 10.1007/s10787-017-0383-7. Epub 2017 Aug 4.
2 Vaccination against chlamydial infections of man and animals. Vet J. 2006 Mar;171(2):263-75. doi: 10.1016/j.tvjl.2004.09.006. Epub 2004 Nov 11.
3 Proteomic analysis of and immune responses to Ehrlichia chaffeensis lipoproteins. Infect Immun. 2008 Aug;76(8):3405-14. doi: 10.1128/IAI.00056-08. Epub 2008 May 19.
4 Gut Mucosal and Fecal Microbiota Profiling Combined to Intestinal Immune System in Neonates Affected by Intestinal Ischemic Injuries. Front Cell Infect Microbiol. 2020 Feb 25;10:59. doi: 10.3389/fcimb.2020.00059. eCollection 2020.
5 Consumption of Dairy Yogurt Containing Lactobacillus paracasei ssp. paracasei, Bifidobacterium animalis ssp. lactis and Heat-Treated Lactobacillus plantarum Improves Immune Function Including Natural Killer Cell Activity. Nutrients. 2017 May 31;9(6):558. doi: 10.3390/nu9060558.
6 HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.
7 Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells. PLoS One. 2020 Feb 11;15(2):e0228531. doi: 10.1371/journal.pone.0228531. eCollection 2020.

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