Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00523)
MIC Name Ehrlichia chaffeensis (alpha-proteobacteria)
Body Site Blood
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Rickettsiales
Family: Anaplasmataceae
Genus: Ehrlichia
Species: Ehrlichia chaffeensis
Microbial Metabolism Utilize cholesterol to survive
Gram Negative
Genome Size (bp) 1176248
Description Ehrlichia chaffeensis is an obligate intracellular, Gram-negative species of Rickettsiales bacteria. It is a zoonotic pathogen transmitted to humans by the lone star tick. It is the causative agent of human monocytic ehrlichiosis.
External Links Taxonomy ID
945
Genome Assembly ID
ASM63286v1
GOLD Organism ID
Go0033515
Host Immune Factors (HIFs)
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description The abundance of Ehrlichia chaffeensis is associated with IFN-Gamma. [1]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description Ehrlichia chaffeensis induces the generation of several cytokines and chemokines by dendritic cells. [1]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Ehrlichia chaffeensis lipoproteins may be able to activate TLR2-expressing neutrophils. [1]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Ehrlichia chaffeensis lipoproteins can activate microbicidal activities of macrophages through Toll-like receptor 2. [1]
          Monocytes
             HIF ID HIFC0024 HIF Info       Class Monocytes (Mono)
             Description Ehrlichia chaffeensis lipoproteins can activate microbicidal activities of monocytes through Toll-like receptor 2. [1]
          Natural Killer cells
             HIF ID HIFC0028 HIF Info       Class Natural killer cells (NKCs)
             Description Ehrlichia chaffeensis lipoproteins may be able to activate NK cells. [1]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Ehrlichia chaffeensis lipoproteins could induce DTH reactions which were elicited by CD4+ and CD8+ T cells of the Th1 subset. [1]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description Ehrlichia chaffeensis leads to the downregulation expression of TLR2. [1]
References
1 Proteomic analysis of and immune responses to Ehrlichia chaffeensis lipoproteins. Infect Immun. 2008 Aug;76(8):3405-14. doi: 10.1128/IAI.00056-08. Epub 2008 May 19.

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