Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0029)
HIF Name	C-C motif chemokine 27
HIF Synonym(s)	Ccl27, cutaneous T-cell-attracting chemokine, CTACK
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Cytokine
Description	CCL27 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.		[1]
Pfam	Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway	Chemokine signaling pathway (hsa04062 )
	Cytokine-cytokine receptor interaction (hsa04060 )
	Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CCL27_HUMAN
	APD ID	AP02193

Microbe Species (MIC) Regulated by This HIF
Candida glabrata (budding yeasts)		MIC01794
Description	Candida antigens can express CCR10, which is the receptor for CCL27.		[2]
Haemophilus ducreyi (gamma-proteobacteria)		MIC00650
Description	CCL27 staining was uniformly positive throughout infected and uninfected sections and appeared unchanged in response to Haemophilus ducreyi infection in the skin.		[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyi.Infect Immun. 2005 Jul;73(7):3896-902. doi: 10.1128/IAI.73.7.3896-3902.2005.

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