General Information of HIF (ID: HIFM0285)
HIF Name	Chromogranin A-N46
HIF Synonym(s)	Cga-N46, CGA-N46
HIF Classification	Antimicrobial peptide (AMP)
Description	CGA-N46 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
External Links
	APD ID	AP01478

Microbe Species (MIC) Regulated by This HIF
Candida glabrata (budding yeasts)			MIC01794
Description	CGA-N46 could inhibite the growth of Candida species by decreasing intracellular reactive oxygen species levels.				[2]
Pichia kudriavzevii (budding yeasts)			MIC01793
Description	The treatment with CGA-N46 increased the average body weight and decreased the mortality of the immunocompromised mice model infected with Candida krusei.				[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Protective effect of a novel antifungal peptide derived from human chromogranin a on the immunity of mice infected with Candida krusei.Exp Ther Med. 2017 May;13(5):2429-2434. doi: 10.3892/etm.2017.4290. Epub 2017 Mar 30.

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