General Information of HIF (ID: HIFM0146)
HIF Name	Interleukin 26
HIF Synonym(s)	IL-26, AK155
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Cytokine
Description	IL-26 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Interleukin 10 (PF00726 )
Pathway	Cytokine-cytokine receptor interaction (hsa04060 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	IL26_HUMAN
	APD ID	AP03086

Microbe Species (MIC) Regulated by This HIF
Escherichia coli (enterobacteria)			MIC00516
Description	The recombinant human IL-26 inhibited the growth of gram-negative bacteria (such as Escherichia coli) by direct bactericidal action and the median minimum inhibitory concentration values were in the range of 8.6 to 18.6 M.				[2]
Klebsiella pneumoniae (enterobacteria)			MIC01405
Description	The recombinant human IL-26 inhibited the growth of gram-negative bacteria, such as Klebsiella pneumonia by direct bactericidal action and the median minimum inhibitory concentration values were in the range of 8.6 to 18.6 M.				[2]
Pseudomonas aeruginosa (gamma-proteobacteria)			MIC01054
Description	The recombinant human (rh) IL-26 inhibited the growth of gram-negative bacteria, such as Pseudomonas aeruginosa by direct bactericidal action and the median minimum inhibitory concentration values were in the range of 8.6 to 18.6 M.				[2]
Staphylococcus aureus (firmicutes)			MIC01208
Description	The recombinant human (rh) IL-26 inhibited the growth of gram-positive bacteria, such as Staphylococcus aureus by direct bactericidal action and the median minimum inhibitory concentration values were in the range of 8.6 to 18.6 M.				[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	IL-26: An Emerging Proinflammatory Member of the IL-10 Cytokine Family with Multifaceted Actions in Antiviral, Antimicrobial, and Autoimmune Responses.PLoS Pathog. 2016 Jun 23;12(6):e1005624. doi: 10.1371/journal.ppat.1005624. eCollection 2016 Jun.

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