Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0110)
HIF Name
T cell immunoglobulin 3
HIF Synonym(s)
Hepatitis A virus cellular receptor 2, HAVCR2, TIM-3
HIF Classification
Checkpoint molecule (CM)
Description T cell immunoglobulin3 (TIM3; also known as Hepatitis A virus cellular receptor 2, HAVCR2), is identified as crucial regulators of the immune response, which motivated the emergence of immune checkpointtargeting therapeutic strategie. [1]
Pfam Immunoglobulin V-set domain (PF07686 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
HAVR2_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Escherichia coli (enterobacteria) MIC00516
             Description TIM-3 expressed in neutrophils is directly involved in reducing the abundance of Escherichia coli. [2]
         Helicobacter pylori (epsilon-proteobacteria) MIC00669
             Description Helicobacter pylori infection significantly elevated Tim-3 mRNA expression levels in RAW264.7 macrophages(p<0.01). [3]
         Pseudomonas aeruginosa (gamma-proteobacteria) MIC01054
             Description The TIM-3 expression on neutrophils has enzymatic activity directly involved in a killing mechanism specific for Pseudomonas aeruginosa. [2]
References
1 Assessment of the expression of the immune checkpoint molecules PD-1, CTLA4, TIM-3 and LAG-3 across different cancers in relation to treatment response, tumor-infiltrating immune cells and survival.Int J Cancer. 2020 Jul 15;147(2):423-439. doi: 10.1002/ijc.32785. Epub 2019 Dec 2.
2 Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung.J Immunol. 2014 Mar 1;192(5):2418-31. doi: 10.4049/jimmunol.1300711. Epub 2014 Jan 29.
3 Overexpression of Tim-3 reduces Helicobacter pylori-associated inflammation through TLR4/NFB signaling invitro.Mol Med Rep. 2017 May;15(5):3252-3258. doi: 10.3892/mmr.2017.6346. Epub 2017 Mar 21.

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