Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0080)
HIF Name	Human beta defensin 4
HIF Synonym(s)	Human Beta Defensin 4, hBD-4, hBD4, BD-4, Beta-defensin 104
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Antibiotic; Antimicrobial; Defensin
Description	Human beta defensin 4 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.		[1]
Pfam	Beta defensin (PF13841 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	D104A_HUMAN
	APD ID	AP00178

Microbe Species (MIC) Regulated by This HIF
Pseudomonas aeruginosa (gamma-proteobacteria)		MIC01054
Description	HBD-4 is bactericidal against Pseudomonas aeruginosa.		[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Bacteria in the intestine, helpful residents or enemies from within. Infect Immun. 2008 Aug;76(8):3360-73. doi: 10.1128/IAI.00187-08. Epub 2008 May 12.

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