General Information of HIF (ID: HIFM0333)
HIF Name	Ubiquicidin
HIF Synonym(s)	Ubiquicidin, UBI 1-59
HIF Classification	Antimicrobial peptide (AMP)
Description	Ubiquicidin has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
External Links
	APD ID	AP02100

Microbe Species (MIC) Regulated by This HIF
Escherichia coli (enterobacteria)			MIC00516
Description	The abundance of Escherichia coli is associated with Ubiquicidin.				[2]
Pseudomonas aeruginosa (gamma-proteobacteria)			MIC01054
Description	Synthesized ubiquicidin (UBI)-loaded micelle to combat Pseudomonas aeruginosa in vitro and in vivo.				[3]
Staphylococcus aureus (firmicutes)			MIC01208
Description	Synthetic peptides derived from human antimicrobial peptide ubiquicidin could accumulate at sites of infections and eradicate (multi-drug resistant) Staphylococcus aureus in mice.				[4]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota.Clin Microbiol Rev. 2006 Apr;19(2):315-37. doi: 10.1128/CMR.19.2.315-337.2006.
3	Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases.Int J Nanomedicine. 2019 Aug 28;14:6937-6956. doi: 10.2147/IJN.S212807. eCollection 2019.
4	Synthetic peptides derived from human antimicrobial peptide ubiquicidin accumulate at sites of infections and eradicate (multi-drug resistant) Staphylococcus aureus in mice.Peptides. 2006 Nov;27(11):2585-91. doi: 10.1016/j.peptides.2006.05.022. Epub 2006 Jul 11.

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