General Information of HGF (ID: HGF0300)
HGF Name	hsa-let-7b-5p
HGF Synonym(s)	microRNA let-7b-5p, MIRLET7b-5p, MIRLET7b-5p
Source	Homo sapiens
HGF Classification	Non-coding RNA: Micro (ncRNA-miRNA)
Gene Location	chr22
Gene Start Site	46113691	Gene End Site		46113712
Strand	Forward (+)
Sequence	Click here to download the HGF sequence in FASTA format
External Links
	miRBase ID	MIMAT0000063

Microbe Species (MIC) Regulated by This HGF
Bacteroides fragilis (CFB bacteria)			MIC00158
Description	The expression of hsa-let-7b-5p could be altered by Bacteroides fragilis.				[1]
Brucella sp. (alpha-proteobacteria)			MIC00274
Description	The let-7b-5p was 1.09-fold up-regulated during Brucella infection.				[2]
Escherichia coli (enterobacteria)			MIC00516
Description	The let-7b overexpression reduced the severity of colitis induced by adherent-invasive Escherichia coli infection in mouse models of Crohns disease.				[1]
Helicobacter pylori (epsilon-proteobacteria)			MIC00669
Description	The level of let-7b expressipon was significantly upregulated with Helicobacter pylori infection (p-value<0.05).				[3]
Lactobacillus johnsonii (firmicutes)			MIC00721
Description	The expression of hsa-let-7b-5p was decreased with the absence of Lactobacillus johnsonii.				[4]
Pseudomonas aeruginosa (gamma-proteobacteria)			MIC01054
Description	The level of let-7b expression was down-regulated 2-fold by Pseudomonas aeruginosa antigens.				[5]

References
1	Inverse relationship between microRNA-155 and -184 expression with increasing conjunctival inflammation during ocular Chlamydia trachomatis infection. Derrick T, Last AR, Burr SE, Roberts CH, Nabicassa M, Cassama E, Bailey RL, Mabey DC, Burton MJ, Holland MJ.. BMC Infect Dis. 2016 Feb 3;16:60. doi: 10.1186/s12879-016-1367-8.
2	Transcriptome microRNA profiling of bovine mammary epithelial cells challenged with Escherichia coli or Staphylococcus aureus bacteria reveals pathogen directed microRNA expression profiles. Jin W, Ibeagha-Awemu EM, Liang G, Beaudoin F, Zhao X, Guan le L.. BMC Genomics. 2014 Mar 7;15:181. doi: 10.1186/1471-2164-15-181.
3	Multifaceted Roles of microRNAs in Host-Bacterial Pathogen Interaction. Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0002-2019.
4	Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development. Genome Med. 2019 Feb 25;11(1):11. doi: 10.1186/s13073-019-0621-2.
5	MicroRNA-762 is upregulated in human corneal epithelial cells in response to tear fluid and Pseudomonas aeruginosa antigens and negatively regulates the expression of host defense genes encoding RNase7 and ST2. PLoS One. 2013;8(2):e57850. doi: 10.1371/journal.pone.0057850. Epub 2013 Feb 28.

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