Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00274)
MIC Name Brucella sp. (alpha-proteobacteria)
Body Site Blood
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Rhizobiales
Family: Brucellaceae
Genus: Brucella
Species: Brucella sp.
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory
Gram Negative
Description Brucella is a genus of Gram-negative bacteria. They are small, nonencapsulated, nonmotile, facultatively intracellular coccobacilli.
External Links Taxonomy ID
52132
GOLD Organism ID
Go0545344
Host Genetic Factors (HGFs)
          hsa-miR-130a-3p
             HGF ID HGF0270 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-130a-3p expression showed significantly upregulated upon Brucella spp. infection (p-value<0.05). [1]
          hsa-miR-142-5p
             HGF ID HGF0649 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-142-5p was 1.25-fold up-regulated during Brucella infection and differentially expressed (p-value=1.86E-307). [2]
          hsa-let-7b-5p
             HGF ID HGF0300 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The let-7b-5p was 1.09-fold up-regulated during Brucella infection. [2]
          hsa-miR-103b
             HGF ID HGF0290 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The serum miR-103b level markedly increased after Brucella infection (p-value<0.05). [3]
          hsa-miR-125b-5p
             HGF ID HGF0278 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-125b-5p was significantly down-regulated in macrophages during Brucella spp.(Brucella abortus) infection (p-value<0.05). [4]
          hsa-miR-146a-5p
             HGF ID HGF0252 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-146a-5p was significantly up-regulated during Brucella infection (Pvalue<0.05). [2]
          hsa-miR-181b-5p
             HGF ID HGF0236 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-181b-5p was 1.50-fold up-regulated during Brucella infection and differentially expressed (p-value=3.63E-261). [2]
          hsa-miR-301a-3p
             HGF ID HGF0174 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-301a-3p was significantly up-regulated upon infection by Brucella spp. (p-value<0.05). [1]
          hsa-miR-92a-3p
             HGF ID HGF0089 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-92a was 1.18-fold up-regulated during Brucella infection. [2]
          hsa-miR-93-5p
             HGF ID HGF0085 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-93 was 1.55-fold down-regulated during Brucella infection. [2]
          hsa-miR-99a-5p
             HGF ID HGF0082 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-99a was 1.12-fold up-regulated during Brucella infection and differentially expressed (p-value=1.02E-163). [2]
          mmu-miR-151-3p
             HGF ID HGF0034 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-151 was 1-fold down-regulated during Brucella infection. [2]
          mmu-miR-1981-5p
             HGF ID HGF0032 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-1981 was 1.19-fold up-regulated during Brucella infection. [2]
          mmu-miR-351-5p
             HGF ID HGF0023 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of mmu-miR-351-5p was significantly up-regulated upon infection by Brucella spp. (p-value<0.05). [1]
Host Immune Factors (HIFs)
          CD163+ M2 macrophages
             HIF ID HIFC0172 HIF Info       Class Macrophages (Mac)
             Description Patients affected by Brucella infection showed lower expression of CD163 M2 macrophages. [5]
          CD206+ M2 macrophages
             HIF ID HIFC0173 HIF Info       Class Macrophages (Mac)
             Description Patients affected by Brucella infection showed lower expression of CD206 M2 macrophages. [5]
          CD80+ M1 macrophages
             HIF ID HIFC0174 HIF Info       Class Macrophages (Mac)
             Description Patients affected by Brucella infection showed lower expression of CD80 M2 macrophages. [5]
          CD86+ M1 macrophages
             HIF ID HIFC0175 HIF Info       Class Macrophages (Mac)
             Description Patients affected by Brucella infection showed lower expression of CD86 M2 macrophages. [5]
Environmental Factor(s)
             Disbiome ID
      1441
References
1 Multifaceted Roles of microRNAs in Host-Bacterial Pathogen Interaction. Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0002-2019.
2 Transcriptome microRNA profiling of bovine mammary epithelial cells challenged with Escherichia coli or Staphylococcus aureus bacteria reveals pathogen directed microRNA expression profiles. Jin W, Ibeagha-Awemu EM, Liang G, Beaudoin F, Zhao X, Guan le L.. BMC Genomics. 2014 Mar 7;15:181. doi: 10.1186/1471-2164-15-181.
3 Comprehensive analysis of differentially expressed serum microRNAs in humans responding to Brucella infection. Ann Transl Med. 2019 Jul;7(14):301. doi: 10.21037/atm.2019.05.74.
4 Altered serum microRNAs as biomarkers for the early diagnosis of pulmonary tuberculosis infection. Qi Y, Cui L, Ge Y, Shi Z, Zhao K, Guo X, Yang D, Yu H, Cui L, Shan Y, Zhou M, Wang H, Lu Z.. BMC Infect Dis. 2012 Dec 28;12:384. doi: 10.1186/1471-2334-12-384.
5 Oral Microbiota and Immune System Crosstalk: A Translational Research.Biology (Basel). 2020 Jun 16;9(6):131. doi: 10.3390/biology9060131.

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