General Information of HIF (ID: HIFM0330)
HIF Name	Thrombin-derived C-terminal Peptide
HIF Synonym(s)	Tcp, TCP
HIF Classification	Antimicrobial peptide (AMP)
Description	TCP has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
External Links
	APD ID	AP01580

Microbe Species (MIC) Regulated by This HIF
Pseudomonas aeruginosa (gamma-proteobacteria)			MIC01054
Description	Pseudomonas aeruginosa elastase cleaves thrombin is associated with the formation of a 21 amino acid TCP.				[2]
Staphylococcus aureus (firmicutes)			MIC01208
Description	C-terminal peptides(TCP) could be found after Staphylococcus aureus bacterial infection.				[3]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Thrombin-Derived Host-Defense Peptides Modulate Monocyte/Macrophage Inflammatory Responses to Gram-Negative Bacteria.Front Immunol. 2017 Jul 21;8:843. doi: 10.3389/fimmu.2017.00843. eCollection 2017.
3	Proteolysis of human thrombin generates novel host defense peptides.PLoS Pathog. 2010 Apr 22;6(4):e1000857. doi: 10.1371/journal.ppat.1000857.

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