General Information of HIF (ID: HIFC0021)
HIF Name	CD68+ macrophages
HIF Synonym(s)	CD68+ macrophages
HIF Classification	Macrophages (Mac)
Description	CD68 is highly expressed by monocytes and tissue macrophages, including Kupffer cells, microglia, histiocytes and osteoclasts, and to a lesser extent on dendritic cells and peripheral blood granulocytes. However CD68 expression is not unique to myeloid cells, it can also be found on hematopoietic and non-hematopoietic cells				[1]

Microbe Species (MIC) Regulated by This HIF
Fusobacterium nucleatum (fusobacteria)			MIC00617
Description	The high abundance of Fusobacterium nucleatum was positively correlated with a high density of CD68+ macrophages(79%;p=0.019).				[2]

References
1	Role of proinflammatory CD68(+) mannose receptor(-) macrophages in peroxiredoxin-1 expression and in abdominal aortic aneurysms in humans.Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):431-8. doi: 10.1161/ATVBAHA.112.300663. Epub 2012 Dec 13.
2	Intratumoral Fusobacterium nucleatum abundance correlates with macrophage infiltration and CDKN2A methylation in microsatellite-unstable colorectal carcinoma.Virchows Arch. 2017 Sep;471(3):329-336. doi: 10.1007/s00428-017-2171-6. Epub 2017 Jun 8.

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