Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00520)
MIC Name Eggerthella lenta (actinobacteria)
MIC Synonyms Bacteroides lentus
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Coriobacteriia
Order: Eggerthellales
Family: Eggerthellaceae
Genus: Eggerthella
Species: Eggerthella lenta
Oxygen Sensitivity Aerobe
Microbial Metabolism Asaccharolytic
Gram Positive
Host Relationship Commensal
Genome Size (bp) 3632260
Description Eggerthella lenta is a species of aerobic, Gram positive, rod shaped bacterium in the phylum Actinobacteria. E. lenta is a commensal organism of the gastrointestinal tract and is rarely associated with infections.
External Links Taxonomy ID
84112
Genome Assembly ID
ASM2426v1
GOLD Organism ID
Go0001217
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Eggerthella lenta was significantly higher in children in the autism spectrum disorder group compared with those in the TD group.. [1]
          Behcet disease  [ICD-11: 4A62]
             Description The abundance of Eggerthella lenta increased significantly in patients with Behcet's disease. [2]
          Rheumatoid arthritis  [ICD-11: FA20]
             Description Eggerthella lenta was associated with genetic variants in Rheumatoid Arthritis. [3]
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Eggerthella lenta was associated with genetic variants in Type 2 diabetes. [3]
Host Genetic Factors (HGFs)
          SHANK3
             HGF ID HGF2351 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of SHANK3 has been significantly associated with the decreased amount of Eggerthella (p-value<0.001). [4]
          VDR
             HGF ID HGF2353 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The percentage of abundance of Eggerthella significantly increased in VDR deletion Mice (p-value<0.05). [5]
          rs3758054
             HGF ID HGF1737 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs3758054 SNP was associated with the abundance of Eggerthellalenta (p-value=2.07E-06). [6]
          rs1420227
             HGF ID HGF1509 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1420227 SNP was associated with the abundance of Eggerthellalenta (p-value=3.12E-07). [6]
          rs1376235
             HGF ID HGF2304 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1376235 SNP was associated with the abundance of Eggerthellalenta (p-value=3.55E-08). [6]
          rs17299191
             HGF ID HGF1508 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs17299191 SNP is significantly associated with the abundance of gut microbiota Eggerthella (p-value<5.00E-05). [7]
          rs1376236
             HGF ID HGF2303 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1376236 SNP is significantly associated with the abundance of gut microbiota Eggerthella (p-value<5.00E-05). [7]
          rs10879524
             HGF ID HGF1642 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10879524 SNP is significantly associated with the abundance of gut microbiota Eggerthella (p-value<5.00E-05). [7]
Host Immune Factors (HIFs)
          C-C motif chemokine 2
             HIF ID HIFM0022 HIF Info       Class Cytokine (Cyt)
             Description At the genus level, Eggerthella is associated with the MCP-1 expression. [8]
          C-C motif chemokine 7
             HIF ID HIFM0034 HIF Info       Class Cytokine (Cyt)
             Description At the genus level, Eggerthella is associated with the MCP-3 expression. [8]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Eggerthella lenta is negatively associated with IgA. [9]
          CD11c+Ly6c+ T cells
             HIF ID HIFC0059 HIF Info       Class T cells (TCs)
             Description Eggerthella lenta induced the production of more numbers of Inflammatory monocytes CD11c+Ly6c+ in rheumatoid arthritis disease. [8]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description Eggerthella lenta induced the production of Th17 cytokines. [8]
Environmental Factor(s)
             Disbiome ID
      4
             gutMDisorder ID
      gm0271
References
1 Alterations in Gut Glutamate Metabolism Associated with Changes in Gut Microbiota Composition in Children with Autism Spectrum Disorder. mSystems. 2019 Jan 29;4(1):e00321-18. doi: 10.1128/mSystems.00321-18. eCollection 2019 Jan-Feb.
2 Relative abundance of Megamonas hypermegale and Butyrivibrio species decreased in the intestine and its possible association with the T cell aberration by metabolite alteration in patients with Behcet's disease (210 characters). Clin Rheumatol. 2019 May;38(5):1437-1445. doi: 10.1007/s10067-018-04419-8. Epub 2019 Jan 9.
3 M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
4 Micron-Size White Bamboo Fibril-Based Silane Cellulose Aerogel: Fabrication and Oil Absorbent Characteristics.Materials (Basel). 2019 Apr 30;12(9):1407. doi: 10.3390/ma12091407.
5 Vitamin D receptor promotes healthy microbial metabolites and microbiome.Sci Rep. 2020 Apr 30;10(1):7340. doi: 10.1038/s41598-020-64226-7.
6 Genetic Determinants of the Gut Microbiome in UK Twins.Cell Host Microbe. 2016 May 11;19(5):731-43. doi: 10.1016/j.chom.2016.04.017.
7 Assessing the Relationship Between Gut Microbiota and Bone Mineral Density.Front Genet. 2020 Jan 31;11:6. doi: 10.3389/fgene.2020.00006. eCollection 2020.
8 Autoimmunity-Associated Gut Commensals Modulate Gut Permeability and Immunity in Humanized Mice. Mil Med. 2019 Mar 1;184(Suppl 1):529-536. doi: 10.1093/milmed/usy309.
9 Impact of a 3-Months Vegetarian Diet on the Gut Microbiota and Immune Repertoire.Front Immunol. 2018 Apr 27;9:908. doi: 10.3389/fimmu.2018.00908. eCollection 2018.

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