General Information of HIF (ID: HIFC0059)
HIF Name	CD11c+Ly6c+ T cells
HIF Synonym(s)	CD11c+Ly6c+, CD11c+Ly6c+ T cells
HIF Classification	T cells (TCs)
Description	An identical CD11b+Ly6C++G- cell population appears to have the ability to adopt immune stimulatory or immune suppressive functions dependent on the presence of a local inflammatory or tumor microenvironment. Thus, there is a functional plasticity in the CD11b+Ly6C++G- cell population that cannot be distinguished with the current molecular markers.				[1]

Microbe Species (MIC) Regulated by This HIF
Eggerthella lenta (actinobacteria)			MIC00520
Description	Eggerthella lenta induced the production of more numbers of Inflammatory monocytes CD11c+Ly6c+ in rheumatoid arthritis disease.				[2]

References
1	CD11b+Ly6C++Ly6G- cells show distinct function in mice with chronic inflammation or tumor burden. BMC Immunol. 2012 Dec 12;13:69. doi: 10.1186/1471-2172-13-69.
2	Autoimmunity-Associated Gut Commensals Modulate Gut Permeability and Immunity in Humanized Mice. Mil Med. 2019 Mar 1;184(Suppl 1):529-536. doi: 10.1093/milmed/usy309.

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