General Information of MIC (ID: MIC01019)
MIC Name	Prevotella nigrescens (CFB bacteria)
Body Site	Oral Cavity
Lineage	Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Prevotellaceae Genus: Prevotella Species: Prevotella nigrescens
Oxygen Sensitivity	Anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Negative
Host Relationship	Commensal
Genome Size (bp)	2612230
Description	Prevotella nigrescens is an anaerobic, Gram negative bacterium. It may play a role in the pathogenesis of periodontal disease. P. nigrescens causes periodontitis by colonizing on the tooth surface and triggering an overly aggressive immune response, which is perceived as inflammation of oral tissue. More recently, P. nigrescens has also been found to be associated with signs of carotid atherosclerosis even in patients without periodontitis and with endodontic infections.
External Links	Taxonomy ID	28133
	Genome Assembly ID	ASM22023v1
	GOLD Organism ID	Go0006390
Disease Relevance
Periodontal disease  [ICD-11: DA0C]
Description	Prevotella nigrescens was associated with periodontal disease.				[1]

Host Immune Factors (HIFs)
Interleukin-1
HIF ID	HIFM0263	HIF Info	Class	Cytokine (Cyt)
Description	Prevotella nigrescens could produce IL-1.				[2]
T helper type 17 cells
HIF ID	HIFC0080	HIF Info	Class	T cells (TCs)
Description	Prevotella nigrescens appeared to favor the induction of TH17 cells in subjects affected by autoimmune experimental arthritis.				[3]
Toll-like receptor 2
HIF ID	HIFM0217	HIF Info	Class	Toll-like receptor (TLR)
Description	Prevotella nigrescens was found to drive Th17 responses in vitro through the production of IL1 by bonemarrowderived dendritic cells in a Tolllike receptor 2 (TLR2) dependent manner.				[2]

Environmental Factor(s)
Disbiome ID			356
gutMDisorder ID			gm0535

References
1	Population-Genomic Insights into Variation in Prevotella intermedia and Prevotella nigrescens Isolates and Its Association with Periodontal Disease. Front Cell Infect Microbiol. 2017 Sep 21;7:409. doi: 10.3389/fcimb.2017.00409. eCollection 2017.
2	The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 2017 Aug;151(4):363-374. doi: 10.1111/imm.12760. Epub 2017 Jun 20.
3	Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer. Microbiol Mol Biol Rev. 2020 Mar 4;84(2):e00064-19. doi: 10.1128/MMBR.00064-19. Print 2020 May 20.

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