Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0065)
HIF Name
Macrophage colony-stimulating factor 1
HIF Synonym(s)
colony stimulating factor 1, CSF1, MCSF
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine; Growth factor
Description A gene on chromosome 1p21-p13 that encodes colony stimulating factor 1 (macrophage), a cytokine that controls the production, differentiation and function of macrophages, and may be involved in development of the placenta. [1]
Pfam Macrophage colony stimulating factor-1 (CSF-1) (PF05337 )
Pathway Alzheimer disease (hsa05010 )
Cytokine-cytokine receptor interaction (hsa04060 )
Hematopoietic cell lineage (hsa04640 )
MAPK signaling pathway (hsa04010 )
Osteoclast differentiation (hsa04380 )
PI3K-Akt signaling pathway (hsa04151 )
Rap1 signaling pathway (hsa04015 )
Ras signaling pathway (hsa04014 )
Rheumatoid arthritis (hsa05323 )
TNF signaling pathway (hsa04668 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CSF1_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Bifidobacterium catenulatum (actinobacteria) MIC00211
             Description Bifidobacterium catenulatum is associated with the expression of M-CSF. [2]
         Bifidobacterium pseudocatenulatum (actinobacteria) MIC00219
             Description Bifidobacterium pseudocatenulatum could decrease the expression of M-CSF. [3]
         Listeria monocytogenes (firmicutes) MIC00771
             Description Listeria monocytogenes is associated with the CSF-1 production. [4]
References
1 CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas.Dis Markers. 2019 Aug 21;2019:2724948. doi: 10.1155/2019/2724948. eCollection 2019.
2 Immunostimulatory effect of faecal Bifidobacterium species of breast-fed and formula-fed infants in a peripheral blood mononuclear cell/Caco-2 co-culture system. Br J Nutr. 2011 Oct;106(8):1216-23. doi: 10.1017/S0007114511001656. Epub 2011 May 31.
3 Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota. Sci Rep. 2017 Aug 18;7(1):8770. doi: 10.1038/s41598-017-09395-8.
4 HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.

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