Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFC0035)
HIF Name	CD4+CD25+ regulatory T cells
HIF Synonym(s)	CD4+CD25+T cells, CD4+CD25+ Tregulatory cells
HIF Classification	T cells (TCs)
Description	CD4 +CD25 + regulatory T cells (Treg ) are instrumental in the maintenance of immunological tolerance. One critical question is whether Treg can only be generated in the thymus or can differentiate from peripheral CD4 +CD25 naive T cells.	[1]

Microbe Species (MIC) Regulated by This HIF
Listeria monocytogenes (firmicutes)		MIC00771
Description	Listeria monocytogenes is associated with CD4+CD25+T cells responses.		[2]

References
1	Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med. 2003 Dec 15;198(12):1875-86. doi: 10.1084/jem.20030152.
2	HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.