General Information of HIF (ID: HIFM0157)
HIF Name	Interferon regulatory factor 3
HIF Synonym(s)	interferon regulatory factor 3, IIAE7
HIF Classification	Cytokine (Cyt)
Molecular Function	Activator; DNA-binding
Description	Transcription factor IRF3-mediated type I interferon induction plays a role in antiviral innate immunity.				[1]
Pfam	Interferon regulatory factor transcription factor (PF00605 )
	Interferon-regulatory factor 3 (PF10401 )
Pathway	Cytosolic DNA-sensing pathway (hsa04623 )
	Epstein-Barr virus infection (hsa05169 )
	Hepatitis B (hsa05161 )
	Hepatitis C (hsa05160 )
	Herpes simplex virus 1 infection (hsa05168 )
	Human cytomegalovirus infection (hsa05163 )
	Human immunodeficiency virus 1 infection (hsa05170 )
	Human papillomavirus infection (hsa05165 )
	Influenza A (hsa05164 )
	Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
	Measles (hsa05162 )
	NOD-like receptor signaling pathway (hsa04621 )
	Pertussis (hsa05133 )
	RIG-I-like receptor signaling pathway (hsa04622 )
	Shigellosis (hsa05131 )
	Toll-like receptor signaling pathway (hsa04620 )
	Viral carcinogenesis (hsa05203 )
	Yersinia infection (hsa05135 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	IRF3_HUMAN

Microbe Species (MIC) Regulated by This HIF
Listeria monocytogenes (firmicutes)			MIC00771
Description	Listeria monocytogenes is associated with IRF3 expression.				[2]

References
1	DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.J Cell Sci. 2019 Jul 24;133(5):jcs230409. doi: 10.1242/jcs.230409.
2	HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.

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