Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0053)
HIF Name
Tumor necrosis factor ligand superfamily member 7
HIF Synonym(s)
CD27-L, CD70
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Cytokine
Description CD70 is reported to be crucial immune modulator. [1]
Pfam TNF(Tumour Necrosis Factor) family (PF00229 )
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CD70_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Citrobacter rodentium (enterobacteria) MIC00366
             Description The lamina propria cells CD70 were associated with the antimicrobial defense and mucosal immunity in against of intestinal pathogen Citrobacter rodentium. [2]
         Listeria monocytogenes (firmicutes) MIC00771
             Description Blockade of CD70 costimulation abrogated the mucosal T cell expansion and effector functions after oral Listeria monocytogenes infection. [3]
References
1 Exploration of a novel prognostic risk signatures and immune checkpoint molecules in endometrial carcinoma microenvironment.Genomics. 2020 Sep;112(5):3117-3134. doi: 10.1016/j.ygeno.2020.05.022. Epub 2020 May 29.
2 The Human Gut Microbiome - A Potential Controller of Wellness and Disease.Front Microbiol. 2018 Aug 14;9:1835. doi: 10.3389/fmicb.2018.01835. eCollection 2018.
3 CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa.Nat Immunol. 2005 Jul;6(7):698-706. doi: 10.1038/ni1212. Epub 2005 Jun 5.

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