General Information of HIF (ID: HIFM0005)
HIF Name	Angiogenin-4
HIF Synonym(s)	Ang4
HIF Classification	Antimicrobial peptide (AMP)
Description	Ang4 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Fibrinogen beta and gamma chains, C-terminal globular domain (PF00147 )
Pathway	HIF-1 signaling pathway (hsa04066 )
	MAPK signaling pathway (hsa04010 )
	PI3K-Akt signaling pathway (hsa04151 )
	Rap1 signaling pathway (hsa04015 )
	Ras signaling pathway (hsa04014 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	ANGP4_HUMAN
	APD ID	AP02075

Microbe Species (MIC) Regulated by This HIF
Bacteroides thetaiotaomicron (CFB bacteria)			MIC00179
Description	The intestinal commensal Bacteroides thetaiotaomicron was less sensitive: the number of viable organisms was reduced only 30% with 1 M of Ang4.				[2]
Enterococcus faecalis (firmicutes)			MIC00548
Description	The number of colony forming units (CFU) of log-phase Enterococcus faecalis(Gram-positive pathogens) declined by>99% after a 2 h exposure to 1 M of Ang4.				[3]
Listeria monocytogenes (firmicutes)			MIC00771
Description	The number of colony forming units (CFU) of log-phase Listeria monocytogenes(Gram-positive pathogens) declined by>99% after a 2 h exposure to 1 M of Ang4.				[3]

References
1	Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.Cell. 2015 Dec 3;163(6):1428-43. doi: 10.1016/j.cell.2015.10.048.
2	Angiogenins: a new class of microbicidal proteins involved in innate immunity.Nat Immunol. 2003 Mar;4(3):269-73. doi: 10.1038/ni888. Epub 2003 Jan 27.
3	Identification, tissue characterization, and innate immune role of Angiogenin-4 expression in young broiler chickens.Poult Sci. 2020 Jun;99(6):2992-3000. doi: 10.1016/j.psj.2020.03.022. Epub 2020 Apr 15.

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