Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0054)
HIF Name
T-lymphocyte activation antigen CD80
HIF Synonym(s)
B7-1, CD80
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Host cell receptor for virus entry; Receptor
Description CD80 is expressed on T cells to regulate responses to self-proteins. [1]
Pfam CD80-like C2-set immunoglobulin domain (PF08205 )
Immunoglobulin V-set domain (PF07686 )
Pathway Allograft rejection (hsa05330 )
Autoimmune thyroid disease (hsa05320 )
Cell adhesion molecules (CAMs) (hsa04514 )
Graft-versus-host disease (hsa05332 )
Intestinal immune network for IgA production (hsa04672 )
Rheumatoid arthritis (hsa05323 )
Systemic lupus erythematosus (hsa05322 )
Toll-like receptor signaling pathway (hsa04620 )
Type I diabetes mellitus (hsa04940 )
Viral myocarditis (hsa05416 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CD80_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Listeria monocytogenes (firmicutes) MIC00771
             Description CD80 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. [2]
References
1 Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.
2 HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.

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