Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0185)
HIF Name
Nucleotide-binding oligomerization domain-containing protein 2
HIF Synonym(s)
nucleotide binding oligomerization domain containing 2, NOD2, CD, ACUG, BLAU, IBD1, YAOS, BLAUS, NOD2B, CARD15, CLR16.3, PSORAS1
HIF Classification
Nod-like receptor (NLR)
Description NLRC2 is a member of the Nucleotide oligomerization domain (NOD)-like receptor (NLR)family NLRC. [1]
Pfam Caspase recruitment domain (PF00619 )
Leucine Rich repeat (PF13516 )
NACHT domain (PF05729 )
NLRC4 helical domain HD2 (PF17776 )
NOD2 winged helix domain (PF17779 )
Pathway Inflammatory bowel disease (IBD) (hsa05321 )
NOD-like receptor signaling pathway (hsa04621 )
TNF signaling pathway (hsa04668 )
Tuberculosis (hsa05152 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
NOD2_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Listeria monocytogenes (firmicutes) MIC00771
             Description Listeria monocytogenes is associated with NOD2 activation. [2]
References
1 Function of Nod-like receptors in microbial recognition and host defense.Immunol Rev. 2009 Jan;227(1):106-28. doi: 10.1111/j.1600-065X.2008.00734.x.
2 HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.

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