Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0233)
HIF Name
Tumor necrosis factor receptor superfamily member 9
HIF Synonym(s)
CD137, 4-1BB, 4-1BB
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Receptor
Description 4-1BB is expressed on T cells to regulate responses to self-proteins. [1]
Pfam TNFR/NGFR cysteine-rich region (PF00020 )
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TNR9_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Akkermansia muciniphila (verrucomicrobia) MIC00056
             Description The abundance of Akkermansia muciniphila is associated with 4-1BB. [2]
         Bacteroides sp. (CFB bacteria) MIC00176
             Description The abundance of Bacteroides is associated with 4-1BB. [2]
         Bifidobacterium sp. (actinobacteria) MIC00224
             Description The abundance of Bifidobacteria is associated with 4-1BB. [2]
         Enterobacter sp. (enterobacteria) MIC00535
             Description The abundance of Enterobacteria is associated with 4-1BB. [2]
         Streptococcus sp. (firmicutes) MIC01276
             Description The abundance of Streptococcus is associated with 4-1BB. [2]
References
1 Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.
2 Microbiome Dependent Regulation of T(regs) and Th17 Cells in Mucosa.Front Immunol. 2019 Mar 8;10:426. doi: 10.3389/fimmu.2019.00426. eCollection 2019.

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