Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00535)
MIC Name Enterobacter sp. (enterobacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Enterobacter
Species: Enterobacter sp.
Oxygen Sensitivity Facultative anaerobe
Gram Negative
Host Relationship Pathogen
Description Enterobacter sp. is a facultative anaerobe, Gram negative species.
External Links Taxonomy ID
42895
GOLD Organism ID
Go0003545
Disease Relevance
          Atherosclerotic cardiovascular disease  [ICD-11: BA5Z]
             Description The abundance of Enterobacteriacae was higher in patients with atherosclerotic cardiovascular disease than in healthy controls. [1]
          Bipolar depression  [ICD-11: 6A60]
             Description The count of Enterobacter spp was higher in subjects with bipolar depression. [2]
          Infectious endocarditis  [ICD-11: BB40]
             Description Enterobacter sp. was associated with infective endocarditis. [3]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Enterobacteriacae is upregulated in disease expression of inflammatory bowel disease. [4]
          Irritable bowel syndrome  [ICD-11: DD91]
             Description The feces of patients with irritable bowel syndrome had higher numbers of Enterobacteriacae compared with controls. [5]
          Obesity  [ICD-11: 5B81]
             Description Obesity was associated with higher prevalence of enterobacteria in children. [6]
          Periodontal disease  [ICD-11: DA0C]
             Description Klebsiella pneumoniae together with other drug-resistant Enterobacteriacae has been previously reported to be present in oral cavities of patients with periodontal disease. [7]
Host Genetic Factors (HGFs)
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The higher AMY1-CN has been significantly associated with the abundance of Enterobacteriaceae (p-value<0.05). [8]
          TLR9
             HGF ID HGF2343 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of TLR9 has been associated with the lower levels of Enterobacteria. [9]
          VIPR2
             HGF ID HGF2350 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of VIPR2 has been associated with the increased abundance of Enterobacter. [10]
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could decrease the abundance of Enterobacteriaceae. [11]
          rs991795
             HGF ID HGF1466 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs991795 SNP was significantly associated with the abundance of Enterobacteriales (p-value=1.77E-05). [12]
          rs9401713
             HGF ID HGF1462 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs9401713 SNP was significantly associated with the abundance of Enterobacteriales (p-value=1.77E-05). [12]
          rs7744763
             HGF ID HGF1465 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7744763 SNP was significantly associated with the abundance of Enterobacteriales (p-value=1.77E-05). [12]
          rs6907236
             HGF ID HGF1464 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6907236 SNP was significantly associated with the abundance of Enterobacteriales (p-value=7.94E-06). [12]
          rs473976
             HGF ID HGF1381 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs473976 SNP was significantly associated with the abundance of Enterobacteriales (p-value=3.46E-06). [12]
          rs35275482
             HGF ID HGF1573 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs35275482 SNP was significantly associated with the abundance of Enterobacteriaceae (p-value=3.72E-11). [13]
          rs17086323
             HGF ID HGF1467 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs17086323 SNP was significantly associated with the abundance of Enterobacteriales (p-value=1.12E-05). [12]
          rs1490360
             HGF ID HGF1469 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1490360 SNP was significantly associated with the abundance of Enterobacteriales (p-value=8.83E-06). [12]
          rs1490359
             HGF ID HGF1471 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1490359 SNP was significantly associated with the abundance of Enterobacteriales (p-value=9.84E-06). [12]
          rs1490350
             HGF ID HGF1463 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1490350 SNP was significantly associated with the abundance of Enterobacteriales (p-value=1.15E-05). [12]
          rs12530266
             HGF ID HGF1470 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12530266 SNP was significantly associated with the abundance of Enterobacteriales (p-value=7.49E-06). [12]
          rs12530210
             HGF ID HGF1472 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12530210 SNP was significantly associated with the abundance of Enterobacteriales (p-value=8.83E-06). [12]
          rs12208734
             HGF ID HGF1473 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12208734 SNP was significantly associated with the abundance of Enterobacteriales (p-value=7.94E-06). [12]
          rs11596374
             HGF ID HGF2267 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs11596374 SNP was significantly associated with the abundance of Enterobacteriales (p-value=9.00E-05). [12]
          rs10872275
             HGF ID HGF1468 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10872275 SNP was significantly associated with the abundance of Enterobacteriales (p-value=7.94E-06). [12]
          rs1078327
             HGF ID HGF1455 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The host NOD2 SNPs(rs1078327) are associated with Enterobacteriaceae abundance in patients with inflammatory bowel disease (p-value<0.05). [14]
          rs8081022
             HGF ID HGF2168 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs8081022 SNP in mucosal immunity pathways influencess the abundance of Enterobacter in the upper airway (p-value=1.56E-06). [15]
          rs6500875
             HGF ID HGF1389 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6500875 SNP in mucosal immunity pathways influences the abundance of Enterobacter in the upper airway (p-value=3.29E-03). [15]
          rs12906972
             HGF ID HGF1781 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12906972 SNP in mucosal immunity pathways influences the abundance of Enterobacter in the upper airway (p-value=9.96E-07). [15]
          rs12446497
             HGF ID HGF1388 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12446497 SNP in mucosal immunity pathways influences the abundance of Enterobacter in the upper airway (p-value=1.90E-05). [15]
          rs11042877
             HGF ID HGF1503 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11042877 SNP in mucosal immunity pathways influences the abundance of Enterobacter in the upper airway (p-value=4.59E-04). [15]
Host Immune Factors (HIFs)
          Melanocyte-stimulating hormone alpha
             HIF ID HIFM0064 HIF Info       Class Antimicrobial peptide (AMP)
             Description Only ClpB from the Enterobacteriaceae family displayed the Alpha-MSH-like functional motifs, linking a relatively small number of specific gut bacteria with the melanocortin system. [16]
          Tumor necrosis factor receptor superfamily member 9
             HIF ID HIFM0233 HIF Info       Class Checkpoint molecule (CM)
             Description The abundance of Enterobacteria is associated with 4-1BB. [17]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Enterobacteriaceae abundance is observed in patients with IBD and in preclinical models.Whether this bloom of microorganisms is related to microbemediated faecal IgA levels is unknown. [18]
Environmental Factor(s)
             Disbiome ID
      42
             gutMDisorder ID
      gm0280
References
1 Alterations in the gut microbiome and metabolism with coronary artery disease severity. Microbiome. 2019 Apr 26;7(1):68. doi: 10.1186/s40168-019-0683-9.
2 Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration. Front Psychiatry. 2019 Oct 29;10:784. doi: 10.3389/fpsyt.2019.00784. eCollection 2019.
3 A broad-range PCR technique for the diagnosis of infective endocarditis. Braz J Microbiol. 2018 Jul-Sep;49(3):534-543. doi: 10.1016/j.bjm.2017.03.019. Epub 2018 Feb 9.
4 Dysbiosis in the pathogenesis of pediatric inflammatory bowel diseases. Int J Inflam. 2012;2012:687143. doi: 10.1155/2012/687143. Epub 2012 May 20.
5 Pathogenic factors involved in the development of irritable bowel syndrome: focus on a microbial role. Infect Dis Clin North Am. 2010 Dec;24(4):961-75, ix. doi: 10.1016/j.idc.2010.07.005.
6 Gut Bifidobacteria Populations in Human Health and Aging. Front Microbiol. 2016 Aug 19;7:1204. doi: 10.3389/fmicb.2016.01204. eCollection 2016.
7 The gut microbiome: scourge, sentinel or spectator. J Oral Microbiol. 2012;4. doi: 10.3402/jom.v4i0.9367. Epub 2012 Feb 21.
8 Human amylase gene copy number variation as a determinant of metabolic state.Expert Rev Endocrinol Metab. 2018 Jul;13(4):193-205. doi: 10.1080/17446651.2018.1499466.
9 Current understanding of the gut microbiota shaping mechanisms.J Biomed Sci. 2019 Aug 21;26(1):59. doi: 10.1186/s12929-019-0554-5.
10 Association of gut microbiota composition and copy number variation with Kasai procedure outcomes in infants with biliary atresia.Pediatr Neonatol. 2020 Apr;61(2):238-240. doi: 10.1016/j.pedneo.2019.12.011. Epub 2020 Jan 7.
11 Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
12 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
13 Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.Nat Genet. 2016 Nov;48(11):1396-1406. doi: 10.1038/ng.3695. Epub 2016 Oct 10.
14 Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: analysis of BMT CTN-0201 and -0901 samples.Br J Haematol. 2018 Sep;182(6):887-894. doi: 10.1111/bjh.15492. Epub 2018 Jul 13.
15 Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.Microbiome. 2017 Feb 1;5(1):16. doi: 10.1186/s40168-016-0227-5.
16 On the origin of eating disorders: altered signaling between gut microbiota, adaptive immunity and the brain melanocortin system regulating feeding behavior.Curr Opin Pharmacol. 2019 Oct;48:82-91. doi: 10.1016/j.coph.2019.07.004. Epub 2019 Aug 17.
17 Microbiome Dependent Regulation of T(regs) and Th17 Cells in Mucosa.Front Immunol. 2019 Mar 8;10:426. doi: 10.3389/fimmu.2019.00426. eCollection 2019.
18 Microbiota and host immune responses: a love-hate relationship. Immunology. 2016 Jan;147(1):1-10. doi: 10.1111/imm.12538. Epub 2015 Nov 2.

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