General Information of HIF (ID: HIFC0038)
HIF Name	RORt+ regulatory T cells
HIF Synonym(s)	RORt+ Tregs, RORt+ Tregulatory cells
HIF Classification	T cells (TCs)
Description	A recent work showed that microbiota-derived secondary bile acids regulate gut ROR+ regulatory T cell homeostasis.				[1]

Microbe Species (MIC) Regulated by This HIF
Bacteroides sp. (CFB bacteria)			MIC00176
Description	Bacteroidales plays an important role in nascent Treg cells that gives rise to disease-suppressing ROR-t+ Treg cells.				[2]
Clostridium sp. (firmicutes)			MIC00418
Description	Clostridiales plays an important role in nascent Treg cells that gives rise to disease-suppressing ROR-t+ Treg cells.				[2]
Erysipelatoclostridium ramosum (firmicutes)			MIC00414
Description	Colonization with Clostridium ramosum (cluster XVIII) has been shown to induce an increase of RORt+ Treg cells.				[3]

References
1	Interaction between microbiota and immunity in health and disease.Cell Res. 2020 Jun;30(6):492-506. doi: 10.1038/s41422-020-0332-7. Epub 2020 May 20.
2	Microbiota therapy acts via a regulatory T cell MyD88/RORt pathway to suppress food allergy. Nat Med. 2019 Jul;25(7):1164-1174. doi: 10.1038/s41591-019-0461-z. Epub 2019 Jun 24.
3	Development and maintenance of intestinal regulatory T cells.Nat Rev Immunol. 2016 May;16(5):295-309. doi: 10.1038/nri.2016.36. Epub 2016 Apr 18.

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