General Information of HIF (ID: HIFC0065)
HIF Name	CD3+CD4+ T cells
HIF Synonym(s)	CD3+CD4+ T-cells, CD3+CD4+ T cells
HIF Classification	T cells (TCs)
Description	Mature CD3 + CD4 + T cells were critical for the development of tertiary lymphoid structures. The initial stages of this process involved interaction of CD3 + CD4 + T cells with DCs, the appearance of peripheral-node addressinpositive (PNAd +) vessels, and production of chemokines that recruit lymphocytes and DCs.				[1]

Microbe Species (MIC) Regulated by This HIF
Bacteroides sp. (CFB bacteria)			MIC00176
Description	Enterotoxigenic Bacteroides fragilis can rapidly induce infiltration of the colonic lamina propria with IL-17-producing CD3+CD4+ T-cells.				[2]

References
1	Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid. Version 2. J Clin Invest. 2006 Oct;116(10):2622-32. doi: 10.1172/JCI28993. Epub 2006 Sep 21.
2	Bacteroides spp. and diarrhea. Curr Opin Infect Dis. 2010 Oct;23(5):470-4. doi: 10.1097/QCO.0b013e32833da1eb.

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