Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0248)
HIF Name	Retinoic acid-related orphan receptor t
HIF Synonym(s)	RAR related orphan receptor gamma t, ROR gamma t
HIF Classification	Retinoic acid receptor (RAR)
Description	RORt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.	[1]

Microbe Species (MIC) Regulated by This HIF
Bacteroides sp. (CFB bacteria)		MIC00176
Description	Commensals of the order Clostridiales and Bacteroidales drive the differentiation of induced Treg (iTreg) cells expressing the transcription factor RORGammat.		[2]

References
1	RORt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol. 2011 Jun;12(6):560-7. doi: 10.1038/ni.2027. Epub 2011 Apr 24.
2	Regulation of oral immune tolerance by the microbiome in food allergy. Curr Opin Immunol. 2019 Oct;60:141-147. doi: 10.1016/j.coi.2019.06.001. Epub 2019 Jul 11.

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