General Information of HIF (ID: HIFC0066)
HIF Name	CD3+CD4+ T cells
HIF Synonym(s)	CD3+CD4 -T-cells, CD3+CD4+ T cells
HIF Classification	T cells (TCs)
Description	CD3 + CD4 + T cells are the major subset of T cells in RPL. These cells are mainly involved in the production of IFN & IL17 in the circulation. Proportion of TGF producing CD3 + CD4 CD8 T cells are less in RPL than in control.				[1]

Microbe Species (MIC) Regulated by This HIF
Bacteroides sp. (CFB bacteria)			MIC00176
Description	Enterotoxigenic Bacteroides fragilis can rapidly induce infiltration of the colonic lamina propria with IL-17-producing CD3+CD4 GammaDelte-T-cells.				[2]

References
1	Peripheral Gamma Delta T cells secrete inflammatory cytokines in women with idiopathic recurrent pregnancy loss. Cytokine. 2018 Feb;102:117-122. doi: 10.1016/j.cyto.2017.07.018. Epub 2017 Aug 9.
2	Bacteroides spp. and diarrhea. Curr Opin Infect Dis. 2010 Oct;23(5):470-4. doi: 10.1097/QCO.0b013e32833da1eb.

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