Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0095)
HIF Name
Elafin
HIF Synonym(s)
Elastase-specific inhibitor, ESI, PI-3, SKALP
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Protease inhibitor; Serine protease inhibitor
Description Elafin has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam Trappin protein transglutaminase binding domain (PF10511 )
WAP-type (Whey Acidic Protein) 'four-disulfide core' (PF00095 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
ELAF_HUMAN
APD ID
AP01587
Microbe Species (MIC) Regulated by This HIF
         Lactococcus lactis (firmicutes) MIC00745
             Description The creation of engineered Lactococcus lactis which produces elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP). [2]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 Microbiota effects on cancer: from risks to therapies.Oncotarget. 2018 Apr 3;9(25):17915-17927. doi: 10.18632/oncotarget.24681. eCollection 2018 Apr 3.

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