Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0045)
HIF Name
B7 homolog 3
HIF Synonym(s)
CD276, 4Ig-B7-H3, Costimulatory molecule
HIF Classification
Checkpoint molecule (CM)
Description B7-H3 is reported to be crucial immune modulator. [1]
Pfam Immunoglobulin V-set domain (PF07686 )
Pathway Cell adhesion molecules (CAMs) (hsa04514 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CD276_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Escherichia coli (enterobacteria) MIC00516
             Description B7-H3 based on its emerging potential as a therapeutic target displayed high expression levels in Escherichia coli. [2]
         Helicobacter pylori (epsilon-proteobacteria) MIC00669
             Description Helicobacter pylori manipulates GECs to differentially express the B7-H3 molecules. [3]
References
1 Exploration of a novel prognostic risk signatures and immune checkpoint molecules in endometrial carcinoma microenvironment.Genomics. 2020 Sep;112(5):3117-3134. doi: 10.1016/j.ygeno.2020.05.022. Epub 2020 May 29.
2 Isolation of rabbit single domain antibodies to B7-H3 via protein immunization and phage display.Antib Ther. 2020 Jan;3(1):10-17. doi: 10.1093/abt/tbaa002. Epub 2020 Feb 17.
3 Helicobacter pylori elicits B7H3 expression on gastric epithelial cells: Implications in local T cell regulation and subset development during infection.Clin Oncol Res. 2019;2(5):10.31487/j.cor.2019.05.05. doi: 10.31487/j.cor.2019.05.05. Epub 2019 Oct 10.

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