General Information of HGF (ID: HGF0303)
HGF Name	hsa-let-7a-5p
HGF Synonym(s)	microRNA let-7a-5p, MIRLET7a-5p, MIRLET7a-5p
Source	Homo sapiens
HGF Classification	Non-coding RNA: Micro (ncRNA-miRNA)
Gene Location	chr22
Gene Start Site	46112752	Gene End Site		46112773
Strand	Forward (+)
Sequence	Click here to download the HGF sequence in FASTA format
External Links
	miRBase ID	MIMAT0000062

Microbe Species (MIC) Regulated by This HGF
Bacillus thuringiensis (firmicutes)			MIC00137
Description	The miRNA hsa-let-7a-5p plays a regulatory role in insect immunity in response to Bacillus thuringiensis.				[1]
Helicobacter pylori (epsilon-proteobacteria)			MIC00669
Description	The expression of let-7a-5p was significantly down-regulated by Helicobacter pylori pathogensa (p-value<0.05).				[2]
Salmonella enterica subsp. enterica (enterobacteria)			MIC01154
Description	The let-7a-5p presents in mesenteric lymph nodes in Salmonella Typhimurium infected pigs.				[3]
Salmonella sp. (enterobacteria)			MIC01149
Description	The level of let-7 miRNA family expression showed significantly downregulated by Salmonella infection (p-value<0.05).				[4]

References
1	MicroRNA expression profiling of Plutella xylostella after challenge with B. thuringiensis. Dev Comp Immunol. 2019 Apr;93:115-124. doi: 10.1016/j.dci.2018.12.008. Epub 2018 Dec 22.
2	Multifaceted Roles of microRNAs in Host-Bacterial Pathogen Interaction. Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0002-2019.
3	Regulatory role of microRNA in mesenteric lymph nodes after Salmonella Typhimurium infection. Vet Res. 2018 Feb 1;49(1):9. doi: 10.1186/s13567-018-0506-1.
4	Effects of Lactobacillus acidophilus and Bifidobacterium bifidum Probiotics on the Expression of MicroRNAs 135b, 26b, 18a and 155, and Their Involving Genes in Mice Colon Cancer. Heydari Z, Rahaie M, Alizadeh AM, Agah S, Khalighfard S, Bahmani S.. Probiotics Antimicrob Proteins. 2019 Dec;11(4):1155-1162. doi: 10.1007/s12602-018-9478-8.

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