General Information of HIF (ID: HIFM0040)
HIF Name	T-cell surface glycoprotein CD1c
HIF Synonym(s)	CD1c, CD1C
HIF Classification	Checkpoint molecule (CM)
Description	CD1molecules(CD1c in human) enables presentation of foreign microbial lipids for specific T cell recognition.				[1]
Pfam	Immunoglobulin C1-set domain (PF07654 )
	MHC-I family domain (PF16497 )
Pathway	Amoebiasis (hsa05146 )
	Hematopoietic cell lineage (hsa04640 )
	Tight junction (hsa04530 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CD1C_HUMAN

Microbe Species (MIC) Regulated by This HIF
Escherichia coli (enterobacteria)			MIC00516
Description	CD1c protein changed the abundance of Escherichia coli.				[2]
Helicobacter pylori (epsilon-proteobacteria)			MIC00669
Description	CD1c may be involved in immune regulation by different bacterial steryl glycosides, including -cholesteryl acylated glucosides from Helicobacter pylori.				[2]

References
1	CD1-dependent dendritic cell instruction.Nat Immunol. 2002 Dec;3(12):1163-8. doi: 10.1038/ni851. Epub 2002 Nov 4.
2	Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1266-75. doi: 10.1073/pnas.1519246113. Epub 2016 Feb 16.

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