General Information of MIC (ID: MIC00145)
MIC Name	Bacteroides acidifaciens (CFB bacteria)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Bacteroidaceae Genus: Bacteroides Species: Bacteroides acidifaciens
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Fermentative
Gram	Negative
Description	Bacteroides acidifaciens is an obligately anaerobic, Gram-negative species.
External Links	Taxonomy ID	85831
	Genome Assembly ID	ASM1020638v1
	GOLD Organism ID	Go0121433

Host Genetic Factors (HGFs)
CD44
HGF ID	HGF2333	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of CD44 significantly decreased the abundance of Bacteroides acidifaciens (p-value<0.05).				[1]
CYP27B1
HGF ID	HGF2312	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of CYP27B1 was significantly decreased the abundance of Bacteroides acidifaciens (p-value<0.05).				[2]
SMARCAD1
HGF ID	HGF2342	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of SMARCAD1 was significantly associated with a decrease of Bacteroides acidifaciens (p-value<0.05).				[3]
hsa-miR-21-5p
HGF ID	HGF0204	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	Bacteroides acidifaciens type A43 resulted in an upregulation of miR-21-5p.				[4]
hsa-miR-375-3p
HGF ID	HGF0674	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	The expression of miR-375-3p was significantly down-regulated by Bacteroides acidifaciens (p-value<0.05).				[4]
hsa-miR-1224-5p
HGF ID	HGF0634	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	The expression of miR-1224 could be altered by Bacteroides acidifaciens.				[4]
hsa-miR-141-3p
HGF ID	HGF0259	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	The abundance of the Bacteroides acidifaciens was correlated with the level of miR-141-3p (p-value<0.05).				[5]
hsa-miR-18a-5p
HGF ID	HGF0238	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	The expression of miR-18a could be altered by Bacteroides acidifaciens.				[4]
hsa-miR-200a-3p
HGF ID	HGF0213	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	Bacteroides acidifaciens-associated lncRNA1 controlled RHEB expression by sponging hsa-miR-200-3p.				[6]

Environmental Factor(s)
Disbiome ID			36
gutMDisorder ID			gm0077

References
1	CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice.Eur J Immunol. 2017 Jul;47(7):1188-1199. doi: 10.1002/eji.201646792. Epub 2017 Jun 6.
2	1,25(OH)(2)D(3) deficiency-induced gut microbial dysbiosis degrades the colonic mucus barrier in Cyp27b1 knockout mouse model.Gut Pathog. 2019 Feb 20;11:8. doi: 10.1186/s13099-019-0291-z. eCollection 2019.
3	Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium.Genome Biol. 2020 Mar 11;21(1):64. doi: 10.1186/s13059-020-01976-7.
4	Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development. Genome Med. 2019 Feb 25;11(1):11. doi: 10.1186/s13073-019-0621-2.
5	Current understanding of the gut microbiota shaping mechanisms.J Biomed Sci. 2019 Aug 21;26(1):59. doi: 10.1186/s12929-019-0554-5.
6	Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure. Croston TL, Nayak AP, Lemons AR, Goldsmith WT, Gu JK, Germolec DR, Beezhold DH, Green BJ.. Clin Exp Allergy. 2016 Oct;46(10):1315-27. doi: 10.1111/cea.12783. Epub 2016 Sep 16.

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