Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00007)
MIC Name Achromobacter xylosoxidans (beta-proteobacteria)
MIC Synonyms Alcaligenes xylosoxidans
Body Site Lung
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Alcaligenaceae
Genus: Achromobacter
Species: Achromobacter xylosoxidans
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory
Gram Negative
Host Relationship Opportunistic pathogen
Genome Size (bp) 6902318
No. of Coding Genes 5257
No. of Non-Coding Genes 72
No. of Small Non-Coding Genes 72
No. of Gene Transcripts 5329
No. of Base Pairs 6902318
Description Achromobacter xylosoxidans is a Gram-negative, aerobic, oxidase and catalase-positive, motile bacterium with peritrichous flagella, from the genus of Achromobacter which exist in water environment and was isolated from patients (pulmonary).
External Links Taxonomy ID
85698
Genome Assembly ID
ASM78343v1
GOLD Organism ID
Go0004665
Disease Relevance
          Cystic fibrosis  [ICD-11: CA25]
             Description Cystic fibrosis was associated with Achromobacter xylosoxidans infection. [1]
          Sepsis  [ICD-11: 1G41]
             Description The presence of sepsis syndrome has evolved as an independent predictor of poor outcome in patients with high-risk malignancies accompanied by Achromobacter bloodstream infections. [2]
Host Immune Factors (HIFs)
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Achromobacter could be preferentially enriched in the IgG-targeted fraction of the microbiota. [3]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description The compartmentalization of Achromobacter xylosoxidans was dependent on the innate lymphoid cells at the gut-immune interface, whose function was associated with CD4 regulatory T cells. [4]
Environmental Factor(s)
             Disbiome ID
      645
             gutMDisorder ID
      gm0004
             aBiofilm Organism
      Achromobacter xylosoxidans
References
1 Identification and distribution of Achromobacter species in cystic fibrosis. J Cyst Fibros. 2013 May;12(3):298-301. doi: 10.1016/j.jcf.2012.10.002. Epub 2012 Nov 7.
2 Bacteremia caused by Achromobacter and Alcaligenes species in 46 patients with cancer (1989-2003). Cancer. 2004 Nov 1;101(9):2134-40. doi: 10.1002/cncr.20604.
3 The antibody/microbiota interface in health and disease.Mucosal Immunol. 2020 Jan;13(1):3-11. doi: 10.1038/s41385-019-0192-y. Epub 2019 Aug 14.
4 Antibody response to Achromobacter xylosoxidans during HIV infection is associated with lower CD4 levels and increased lymphocyte activation. Clin Vaccine Immunol. 2014 Jan;21(1):46-50. doi: 10.1128/CVI.00553-13. Epub 2013 Oct 30.

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