Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00442)
MIC Name Coprococcus comes (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Coprococcus
Species: Coprococcus comes
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 3238915
Description Coprococcus comes is an anaerobi,Gram-positive coccoid rod isolated from the faecal flora of patients with Crohn's disease. The bacteria is more frequently found in sera of Crohn patients than in ulcerative colitis patients and healthy subjects.
External Links Taxonomy ID
410072
Genome Assembly ID
ASM15587v1
GOLD Organism ID
Go0000906
Disease Relevance
          Crohn disease  [ICD-11: DD70]
             Description Sera from patients with Crohn's disease contained more agglutinins against anaerobic coccoid rods, identified as Coprococcus comes. [1]
          Obesity  [ICD-11: 5B81]
             Description Coprococcus comes was associated with genetic variants in Obesity. [2]
Host Immune Factors (HIFs)
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Coprococcus comes, Dorea sp., and Clostridium sp. thrive in the presence of IgA. [3]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Relative abundance of Coprococcus comes was associated with CD4+ T-cell counts. [4]
Environmental Factor(s)
             Disbiome ID
      1148
             gutMDisorder ID
      gm0224
References
1 Induction in rats of serum agglutinins to Eubacterium, Peptostreptococcus and Coprococcus species by the faecal flora from patients with Crohn's disease and healthy subjects. J Hyg (Lond). 1984 Oct;93(2):345-8. doi: 10.1017/s0022172400064895.
2 M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
3 The antibody/microbiota interface in health and disease.Mucosal Immunol. 2020 Jan;13(1):3-11. doi: 10.1038/s41385-019-0192-y. Epub 2019 Aug 14.
4 Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients. Front Microbiol. 2018 Jul 2;9:1451. doi: 10.3389/fmicb.2018.01451. eCollection 2018.

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