General Information of MIC (ID: MIC00038)
MIC Name	Actinomyces viscosus (actinobacteria)
MIC Synonyms	Odontomyces viscosus
Body Site	Oral Cavity
Lineage	Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Actinomycetales Family: Actinomycetaceae Genus: Actinomyces Species: Actinomyces viscosus
Oxygen Sensitivity	Facultative anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Positive
Host Relationship	Pathogen
Genome Size (bp)	3132692
Description	Actinomyces viscosus is a facultatively anaerobic, Gram positive human and animal pathogen/pathobiont which colonises the mouths of 70% of adult humans. It has a low level of virulence and is often mistaken with other actinomycetes.
External Links	Taxonomy ID	1656
	Genome Assembly ID	Acti_vis_C505_V3
	GOLD Organism ID	Go0004620
Disease Relevance
Female pelvic inflammatory disease  [ICD-11: GA05]
Description	Pelvic inflammatory disease was associated with Actinomyces viscosus.				[1]
Type 2 diabetes mellitus  [ICD-11: 5A11]
Description	Actinomyces viscosus was associated with type 2 diabetes.				[2]

Host Genetic Factors (HGFs)
rs34107488
HGF ID	HGF1305	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs34107488 SNP was significantly associated with the abundance of Actinomyces viscosus (p-value<1.00E-08).				[3]

Host Immune Factors (HIFs)
CD4+ regulatory T cells
HIF ID	HIFC0034	HIF Info	Class	T cells (TCs)
Description	CD4+ cells may mediate oral tolerance of cellular immunity induced by low doses of Actinomyces viscosus.				[4]
CD8+ T cells
HIF ID	HIFC0073	HIF Info	Class	T cells (TCs)
Description	CD8+ cells may mediate oral tolerance of humoral immunity induced by low doses of Actinomyces viscosus.				[4]

Environmental Factor(s)
Disbiome ID			344
gutMDisorder ID			gm0018

References
1	Actinomyces species associated with intrauterine contraceptive devices and pelvic inflammatory disease. Indian J Pathol Microbiol. 1993 Jul;36(3):238-44.
2	Global metabolic interaction network of the human gut microbiota for context-specific community-scale analysis. Nat Commun. 2017 Jun 6;8:15393. doi: 10.1038/ncomms15393.
3	Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
4	Role of CD4 and CD8 T-cells in the induction of oral tolerance to Actinomyces viscosus in mice. Oral Microbiol Immunol. 2006 Jun;21(3):151-8. doi: 10.1111/j.1399-302X.2006.00263.x.

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