Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01339)
MIC Name Turicibacter (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Erysipelotrichia
Order: Erysipelotrichales
Family: Erysipelotrichaceae
Genus: Turicibacter
Oxygen Sensitivity Strictly anaerobe
Microbial Metabolism Fermentative
Gram Positive
Description Turicibacter is a genus in the Firmicutes phylum of bacteria that has most commonly been found in the gut of animals.
External Links Taxonomy ID
191303
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Turicibacter sp. was significantly elevated in autistic children. [1]
Host Genetic Factors (HGFs)
          15q11-13
             HGF ID HGF2318 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The duplicaton of 15q is assciated with the reduction of the relative abundance of Turicibacter caused by ampicillin (p-value<0.05). [2]
          ARNTL
             HGF ID HGF2325 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of BMAL1 could increase relative abundances of Turicibacter (p-value<0.05). [3]
          MUC2
             HGF ID HGF2331 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of MUC2 showed increased abundance of Turicibacter. [4]
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could decrease the abundance of Turicibacter. [5]
          rs29327022
             HGF ID HGF2585 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs29327022 SNP is associated with the heritable variation in Turicibacter. [6]
          rs6338556
             HGF ID HGF2586 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6338556 SNP is associated with the heritable variation in Turicibacter. [6]
          rs6265280
             HGF ID HGF2587 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6265280 SNP is associated with the heritable variation in Turicibacter. [6]
Host Immune Factors (HIFs)
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description Turicibacter species can modulate CD8+ T cells responses. [7]
Environmental Factor(s)
             Disbiome ID
      134
             gutMDisorder ID
      gm0653
References
1 The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115.
2 Altered microbiota composition reflects enhanced communication in 15q11-13 CNV mice.Neurosci Res. 2019 Dec 18:S0168-0102(19)30671-6. doi: 10.1016/j.neures.2019.12.010. Online ahead of print.
3 Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock.Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10479-84. doi: 10.1073/pnas.1501305112. Epub 2015 Aug 3.
4 The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice.Int J Mol Sci. 2018 Sep 18;19(9):2809. doi: 10.3390/ijms19092809.
5 Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
6 Complex host genetics influence the microbiome in inflammatory bowel disease. Genome Med. 2014 Dec 2;6(12):107. doi: 10.1186/s13073-014-0107-1. eCollection 2014.
7 Protein Malnutrition Alters Tryptophan and Angiotensin-Converting Enzyme 2 Homeostasis and Adaptive Immune Responses in Human Rotavirus-Infected Gnotobiotic Pigs with Human Infant Fecal Microbiota Transplant.Clin Vaccine Immunol. 2017 Aug 4;24(8):e00172-17. doi: 10.1128/CVI.00172-17. Print 2017 Aug.

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