Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00966)
MIC Name Pasteurella dagmatis (gamma-proteobacteria)
Body Site Nose
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pasteurellales
Family: Pasteurellaceae
Genus: Pasteurella
Species: Pasteurella dagmatis
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Description Pasteurella multocida, a facultatively anaerobic, Gram-negative, nonmotile coccobacillus, causes snuffles in rabbits and may be considered a zoonotic disease.
External Links Taxonomy ID
754
Genome Assembly ID
ASM16347v1
GOLD Organism ID
Go0398318
Disease Relevance
          Osteomyelitis or osteitis  [ICD-11: FB84]
             Description Endocarditis was associated with Pasteurella dagmatis infection. [1]
          Parkinsonism  [ICD-11: 8A00]
             Description Pasteurellaceae was associated with parkinsons disease. [2]
          Peritonitis  [ICD-11: DC50]
             Description Pasteurella dagmatis can cause peritonitis. [3]
          Prosthetic valve disease  [ICD-11: BC01]
             Description Pasteurella dagmatis can cause prosthetic valve endocarditis. [3]
          Sepsis  [ICD-11: 1G41]
             Description Pasteurella dagmatis can cause septicaemia. [3]
          Vertebral osteomyelitis  [ICD-11: FA90]
             Description Pasteurella dagmatis can cause vertebral osteomyelitis. [3]
Host Genetic Factors (HGFs)
          rs906351
             HGF ID HGF2286 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs906351 SNP was significantly associated with the abundance of Pasteurellaceae (p-value=2.73E-07). [4]
          rs8107969
             HGF ID HGF1226 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs8107969 SNP is significantly associated with the abundance of Pasteurellaceae (p-value=2.40696E-07). [5]
          rs2843167
             HGF ID HGF2288 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2843167 SNP was significantly associated with the abundance of Pasteurellaceae (p-value=1.26E-06). [4]
          rs2288868
             HGF ID HGF1227 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs2288868 SNP is significantly associated with the abundance of Pasteurellaceae (p-value=2.56352E-07). [5]
          rs1395747
             HGF ID HGF2290 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1395747 SNP was significantly associated with the abundance of Pasteurellaceae (p-value=3.10E-07). [4]
          rs10494924
             HGF ID HGF2287 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10494924 SNP was significantly associated with the abundance of Pasteurellaceae (p-value=1.26E-06). [4]
          rs1021993
             HGF ID HGF2289 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1021993 SNP was significantly associated with the abundance of Pasteurellaceae (p-value=2.24E-07). [4]
Host Immune Factors (HIFs)
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description An attenuated Actinobacillus pleuropneumoniae serovar 1 live vaccine prototype stimulated gamma interferon (IFN-) production. [6]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Pasteurellaceae was associated with Th1-type immune response. [6]
Environmental Factor(s)
             Disbiome ID
      820
References
1 Infective endocarditis due to Pasteurella dagmatis: case report and review. Clin Infect Dis. 1994 Mar;18(3):336-8. doi: 10.1093/clinids/18.3.336.
2 Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome. Mov Disord. 2017 May;32(5):739-749. doi: 10.1002/mds.26942. Epub 2017 Feb 14.
3 Bacteremia due to Pasteurella dagmatis acquired from a dog bite, with a review of systemic infections and challenges in laboratory identification. Can J Infect Dis Med Microbiol. 2015 Sep-Oct;26(5):273-6. doi: 10.1155/2015/946812.
4 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
5 Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.Gut. 2020 Jul 10:gutjnl-2019-319706. doi: 10.1136/gutjnl-2019-319706. Online ahead of print.
6 The live attenuated Actinobacillus pleuropneumoniae triple-deletion mutant apxIC apxIIC apxIV-ORF1 strain, SLW05, Immunizes pigs against lethal challenge with Haemophilus parasuis. Clin Vaccine Immunol. 2013 Feb;20(2):134-9. doi: 10.1128/CVI.00458-12. Epub 2012 Dec 5.

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