Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01116)
MIC Name Roseburia faecis (firmicutes)
MIC Synonyms Agathobacter faecis
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Roseburia
Species: Roseburia faecis
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic
Gram Positive
Genome Size (bp) 3334694
No. of Coding Genes 3168
No. of Non-Coding Genes 54
No. of Small Non-Coding Genes 54
No. of Gene Transcripts 3222
No. of Base Pairs 3334694
Description Roseburia faecis is an anaerobic, Gram positive bacterium. In a study, the bacterium showed decreased abundance in colorectal cancer patients with blood in their stools.
External Links Taxonomy ID
301302
Genome Assembly ID
ASM971840v1
GOLD Organism ID
Go0449803
Disease Relevance
          Colorectal cancer  [ICD-11: 2B91]
             Description Roseburia faecis showed decreased abundance in colorectal cancer patients with blood in their stools. [1]
Host Genetic Factors (HGFs)
          rs17229285
             HGF ID HGF2578 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs17229285 SNP is associated with the abundance of Roseburia faecis. [2]
          rs259964
             HGF ID HGF2645 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs259964 SNP is associated with the abundance of Roseburia faecis. [2]
          rs11739663
             HGF ID HGF2527 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs11739663 SNP is associated with the abundance of Roseburia faecis. [2]
          rs38911
             HGF ID HGF2577 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs38911 SNP is associated with the abundance of Roseburia faecis. [2]
          rs12994997
             HGF ID HGF2541 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12994997 SNP is associated with the abundance of Roseburia faecis. [2]
          rs9297145
             HGF ID HGF2622 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs9297145 SNP is associated with the abundance of Roseburia faecis. [2]
          rs6074022
             HGF ID HGF2569 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6074022 SNP is associated with the abundance of Roseburia faecis. [2]
          rs11879191
             HGF ID HGF2623 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11879191 SNP is associated with the abundance of Roseburia faecis. [2]
          rs7015630
             HGF ID HGF2646 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7015630 SNP is associated with the abundance of Roseburia faecis. [2]
Host Immune Factors (HIFs)
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description The mRNA expression levels of L-10 negatively correlated (p < 0.05) with the abundance of OTU related to Roseburia faecis. [3]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description The mRNA expression levels of IL-1Beta, IL-10, IFN-Gamma, and TNF-Alpha negatively correlated (p < 0.05) with the abundance of OTU related to Roseburia faecis. [3]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description The mRNA expression levels of IL-1Beta, IL-10, IFN-Gamma, and TNF-Alpha negatively correlated (p<0.05) with the abundance of OTU related to Roseburia faecis. [3]
          Immunoglobulin G2
             HIF ID HIFM0268 HIF Info       Class Immunoglobulin (Ig)
             Description IgG2 could response against Roseburia faecis. [4]
          Immunoglobulin G1
             HIF ID HIFM0269 HIF Info       Class Immunoglobulin (Ig)
             Description Prediagnosis IgG2 titers could be against the Roseburia faecis strain. [4]
Environmental Factor(s)
             Disbiome ID
      602
             gutMDisorder ID
      gm0572
References
1 The influence of blood on the human gut microbiome. BMC Microbiol. 2020 Mar 3;20(1):44. doi: 10.1186/s12866-020-01724-8.
2 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
3 Effects of Intranasal Pseudorabies Virus AH02LA Infection on Microbial Community and Immune Status in the Ileum and Colon of Piglets. Viruses. 2019 Jun 5;11(6):518. doi: 10.3390/v11060518.
4 Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children.Sci Immunol. 2019 Feb 1;4(32):eaau8125. doi: 10.1126/sciimmunol.aau8125.

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