Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00205)
MIC Name Bifidobacterium adolescentis (actinobacteria)
MIC Synonyms Bifidobacterium stercoris
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: Bifidobacterium adolescentis
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 2203222
No. of Coding Genes 1725
No. of Non-Coding Genes 67
No. of Small Non-Coding Genes 67
No. of Gene Transcripts 1792
No. of Base Pairs 2203222
Description Bifidobacterium adolescentis is a normal obligate anaerobic, Gram positive inhabitant of the healthy human gut. This species was first isolated from the feces of a breast-fed infant. It was found a beneficial probiotic for human.
External Links Taxonomy ID
1680
Genome Assembly ID
ASM73788v1
GOLD Organism ID
Go0517356
Disease Relevance
          Asthma  [ICD-11: CA23]
             Description Bifidobacterium adolescentis was associated with asthma. [1]
          Coeliac disease  [ICD-11: DA95]
             Description Bacterial counts of Bifidobacterium adolescentis increased when the genetic risk of coeliac disease was increased. [2]
          Retinal artery occlusions  [ICD-11: 9B74]
             Description On the phylum level, the relative abundance of Bacteroidetes was decreased in patients with RAO compared to controls, whereas the opposite applied for the phylum of Proteobacteria. Several genera and species such as Actinobacter, Bifidobacterium spp., Bacteroides stercoris, Faecalibacterium prausnitzii were relatively enriched in patients with RAO, whereas others such as Odoribacter, Parasutterella or Lachnospiraceae were significantly lower [3]
Host Genetic Factors (HGFs)
          LCT
             HGF ID HGF2323 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of LCT is significantly associated with the abundance of Bifidobacterium adolescentis (p-value<0.05). [4]
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could decrease the abundance of Bifidobacterium adolescentis. [5]
          rs651821
             HGF ID HGF1924 HGF Info       Class Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
             Description The APOA5 SNP rs651821 might be an important host genetic factor in determining the abundances of the health-promoting Bifidobacterium bacteria and the taxa to which this genus belongs. [6]
          rs2457996
             HGF ID HGF2540 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2457996 SNP is associated with the abundance of Bifidobacterium adolescentis. [7]
          rs7608910
             HGF ID HGF2613 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7608910 SNP is associated with the abundance of Bifidobacterium adolescentis. [7]
          rs1250546
             HGF ID HGF2565 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1250546 SNP is associated with the abundance of Bifidobacterium adolescentis. [7]
          rs12994997
             HGF ID HGF2541 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12994997 SNP is associated with the abundance of Bifidobacterium adolescentis. [7]
          rs38911
             HGF ID HGF2577 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs38911 SNP is associated with the abundance of Bifidobacterium adolescentis. [7]
          rs7097656
             HGF ID HGF2572 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7097656 SNP is associated with the abundance of Bifidobacterium adolescentis. [7]
          rs6708413
             HGF ID HGF2544 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6708413 SNP is associated with the abundance of Bifidobacterium adolescentis. [7]
          rs1363907
             HGF ID HGF2539 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1363907 SNP is associated with the abundance of Bifidobacterium adolescentis. [7]
          rs2503322
             HGF ID HGF2614 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2503322 SNP is associated with the abundance of Bifidobacterium adolescentis. [7]
          rs2227551
             HGF ID HGF2615 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2227551 SNP is associated with the abundance of Bifidobacterium adolescentis. [7]
Host Immune Factors (HIFs)
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Bifidobacterium adolescentis could inhibite IFN-Gamma production. [8]
Environmental Factor(s)
             Disbiome ID
      22
             gutMDisorder ID
      gm0106
References
1 Gut Bifidobacteria Populations in Human Health and Aging. Front Microbiol. 2016 Aug 19;7:1204. doi: 10.3389/fmicb.2016.01204. eCollection 2016.
2 Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study. PLoS One. 2012;7(2):e30791. doi: 10.1371/journal.pone.0030791. Epub 2012 Feb 3.
3 Retinal artery occlusion is associated with compositional and functional shifts in the gut microbiome and altered trimethylamine-N-oxide levels. Sci Rep. 2019 Oct 25;9(1):15303. doi: 10.1038/s41598-019-51698-5.
4 Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.Gut. 2020 Jul 10:gutjnl-2019-319706. doi: 10.1136/gutjnl-2019-319706. Online ahead of print.
5 Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
6 The effect of heritability and host genetics on the gut microbiota and metabolic syndrome.Gut. 2017 Jun;66(6):1031-1038. doi: 10.1136/gutjnl-2015-311326. Epub 2016 Apr 6.
7 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
8 Immunostimulatory effect of faecal Bifidobacterium species of breast-fed and formula-fed infants in a peripheral blood mononuclear cell/Caco-2 co-culture system. Br J Nutr. 2011 Oct;106(8):1216-23. doi: 10.1017/S0007114511001656. Epub 2011 May 31.

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