General Information of HIF (ID: HIFC0006)
HIF Name	CD103+ dendritic cells
HIF Synonym(s)	CD103+ DCs, CD103+ dendritic cells
HIF Classification	Dendritic cells (DCs)
Description	To explore the role of CD103+ DCs and the potential mechanisms underlying MSCs-mediated protective effects in DN, we used bone marrow MSCs (BM-MSCs) to treat DN rats. MSCs transplantation considerably recovered kidney function and diminished renal injury, fibrosis and the population of renal CD103+ DCs in DN rat				[1]

Microbe Species (MIC) Regulated by This HIF
Bacteroides fragilis (CFB bacteria)			MIC00158
Description	Intestinal CD103+ dendritic cells are induced by oral administration of polysaccharide A from Bacteroides fragilis.				[2]
Kluyveromyces marxianus (budding yeasts)			MIC01976
Description	Oral administration of Candida kefyr is associated with the increase of CD103-positive regulatory dendritic cells in MLNs.				[2]
Staphylococcus epidermidis (firmicutes)			MIC01214
Description	Staphylococcus epidermidis can interact with CD103+ DCs to enhance barrier function.				[3]

References
1	Mesenchymal stem cells alleviate rat diabetic nephropathy by suppressing CD103(+) DCs-mediated CD8(+) T cell responses. J Cell Mol Med. 2020 May;24(10):5817-5831. doi: 10.1111/jcmm.15250. Epub 2020 Apr 13.
2	Dietary Yeasts Reduce Inflammation in Central Nerve System via Microflora.Ann Clin Transl Neurol. 2015 Jan;2(1):56-66. doi: 10.1002/acn3.153. Epub 2014 Dec 3.
3	Microbiota and host immune responses: a love-hate relationship. Immunology. 2016 Jan;147(1):1-10. doi: 10.1111/imm.12538. Epub 2015 Nov 2.

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