Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00596)
MIC Name Finegoldia magna (firmicutes)
MIC Synonyms Diplococcus magnus
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Tissierellia
Order: Tissierellales
Family: Peptoniphilaceae
Genus: Finegoldia
Species: Finegoldia magna
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Asaccharolytic
Gram Positive
Genome Size (bp) 1986740
No. of Coding Genes 1819
No. of Non-Coding Genes 38
No. of Small Non-Coding Genes 38
No. of Gene Transcripts 1857
No. of Base Pairs 1824890
Description Finegoldia magna is a species of obligately anaerobic, Gram positive bacterium. It is a normal flora of the gastrointestinal and genitourinary tract, and can be isolated from skin and the oral cavity and is often regarded as a contaminant in cultures. It is an opportunist organism often found in abdominal infections (where it does not seem to cause serious problems), non-puerperal breast abscesses and diabetic foot infections.
External Links Taxonomy ID
1260
Genome Assembly ID
ASM154638v1
GOLD Organism ID
Go0006784
Disease Relevance
          Urinary tract infection  [ICD-11: GC08]
             Description Finegoldia magna was associated with preoperative urinary symptom severity in women undergoing POP/SUI surgery. [1]
Host Genetic Factors (HGFs)
          rs9805042
             HGF ID HGF1936 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs9805042 SNP was significantly associated with the abundance of Peptococcus (p-value=1.87E-06). [2]
Host Immune Factors (HIFs)
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description IgM has regulatory affinity which could bind to Peptococcus magnus strain. [3]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Peptococcus is associated with IgG immune responses. [3]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description IgA has regulatory affinity which could bind to Peptococcus magnus strain. [3]
Environmental Factor(s)
             Disbiome ID
      791
             gutMDisorder ID
      gm0331
References
1 Urinary symptoms are associated with certain urinary microbes in urogynecologic surgical patients. Int Urogynecol J. 2018 Dec;29(12):1765-1771. doi: 10.1007/s00192-018-3732-1. Epub 2018 Aug 16.
2 Host genetic variation impacts microbiome composition across human body sites.Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
3 A non-immune interaction between the light chain of human immunoglobulin and a surface component of a Peptococcus magnus strain. Mol Immunol. 1985 Aug;22(8):879-85. doi: 10.1016/0161-5890(85)90073-2.

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