Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00444)
MIC Name Coprococcus sp. (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Coprococcus
Species: Coprococcus sp.
Oxygen Sensitivity Anaerobe
Microbial Metabolism Fermentative
Gram Positive
Description Coprococcus sp. is an anaerobic, Gram positive bacterium of the genus Coprococcus.
External Links Taxonomy ID
2049024
GOLD Organism ID
Go0546679
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Coprococcus had marginally low relative abundance in the autism spectrum disorder. [1]
          Autoimmune liver disease  [ICD-11: DB96]
             Description Coprococcus was decreased in patients with primary sclerosing cholangitis. [2]
          Crohn disease  [ICD-11: DD70]
             Description Coprococcus sp. was associated with crohns disease. [3]
          Ulcerative colitis  [ICD-11: DD71]
             Description Coprococcus was decreased in ulcerative colitis patients. [2]
Host Genetic Factors (HGFs)
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could decrease the abundance of unclassified Coprococcus. [4]
          MIR21
             HGF ID HGF2332 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of MIR-21 was significantly increased the proportion of Coprococcus (p-value<0.05). [5]
          rs786402
             HGF ID HGF1887 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs786402 SNP was significantly associated with the abundance of Coprococcus (p-value=1.44E-06). [6]
          rs722075
             HGF ID HGF1240 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs722075 SNP was significantly associated with the abundance of Coprococcus (p-value=1.45E-06). [6]
          rs6747870
             HGF ID HGF1267 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6747870 SNP was significantly associated with the abundance of Coprococcus (p-value=2.88E-07). [7]
          rs6656158
             HGF ID HGF2295 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6656158 SNP was significantly associated with the abundance of Coprococcus (p-value=1.02E-07). [6]
          rs3739036
             HGF ID HGF2136 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs3739036 SNP was significantly associated with the abundance of Coprococcus (p-value=2.69E-07). [7]
          rs3739034
             HGF ID HGF2137 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs3739034 SNP was significantly associated with the abundance of Coprococcus (p-value=1.36E-07). [7]
          rs2475321
             HGF ID HGF1522 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2475321 SNP was significantly associated with the abundance of Coprococcus (p-value=9.20E-08). [6]
          rs2293702
             HGF ID HGF1370 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2293702 SNP was significantly associated with the abundance of Coprococcus (p-value=1.41E-08). [6]
          rs2066842
             HGF ID HGF1456 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The variant gene NOD2 of innate immunity rs2066842 is significantly associated with the abundance of gut micriobiota Coprococcus (p-value<0.0001). [8]
          rs12606140
             HGF ID HGF1703 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12606140 SNP was significantly associated with the abundance of Coprococcus (p-value=2.17E-07). [6]
          rs11123259
             HGF ID HGF1818 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11123259 SNP was significantly associated with the abundance of Coprococcus (p-value=8.47E-07). [7]
          rs10496481
             HGF ID HGF1817 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10496481 SNP was significantly associated with the abundance of Coprococcus (p-value=8.47E-07). [7]
Host Immune Factors (HIFs)
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description IgG immune responses is associated with Coprococcus. [9]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Coprococcus was significantly enriched in the IgA(Low or no IgA binding) consortia. [10]
Environmental Factor(s)
             Disbiome ID
      128
             gutMDisorder ID
      gm0223
References
1 Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders. Anaerobe. 2018 Feb;49:121-131. doi: 10.1016/j.anaerobe.2017.12.007. Epub 2017 Dec 22.
2 Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
3 Genome sequence and description of Coprococcus phoceensis gen. nov., sp. nov., a new bacterial genus isolated from the human left colon. New Microbes New Infect. 2019 Apr 10;30:100548. doi: 10.1016/j.nmni.2019.100548. eCollection 2019 Jul.
4 Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
5 Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis.J Crohns Colitis. 2018 Jun 28;12(7):835-848. doi: 10.1093/ecco-jcc/jjy038.
6 Genetic Determinants of the Gut Microbiome in UK Twins.Cell Host Microbe. 2016 May 11;19(5):731-43. doi: 10.1016/j.chom.2016.04.017.
7 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
8 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
9 The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients. Scand J Immunol. 2019 Sep;90(3):e12799. doi: 10.1111/sji.12799. Epub 2019 Jul 8.
10 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.

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