Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01150)
MIC Name Salmonella enterica (enterobacteria)
MIC Synonyms Salmonella choleraesuis
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella enterica
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Fermentative or Respiratory; Utilize variety of carbon sources
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 5133713
No. of Coding Genes 4472
No. of Non-Coding Genes 113
No. of Small Non-Coding Genes 113
No. of Gene Transcripts 4585
No. of Base Pairs 4786542
Description Salmonella enterica is a rod-shaped, flagellate, facultative anaerobic, Gram-negative bacterium and a species of the genus Salmonella. A number of its serovars are serious human pathogens. For example, S. enterica serovar Typhimurium, which can cause human diarrhea.
External Links Taxonomy ID
28901
Genome Assembly ID
ASM78381v1
GOLD Organism ID
Go0075283
Host Genetic Factors (HGFs)
          hsa-miR-3525
             HGF ID HGF0669 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-3525 expression showed significantly upregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-215-5p
             HGF ID HGF0661 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-215-5p expression showed significantly downregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-193a-5p
             HGF ID HGF0658 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-193a-5p expression showed significantly upregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-1662
             HGF ID HGF0654 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-1662 expression showed significantly downregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-1416-5p
             HGF ID HGF0647 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-1416-5p expression showed significantly upregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-1308
             HGF ID HGF0642 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-1308 expression showed significantly upregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-1-3p
             HGF ID HGF0294 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-1-3p was significantly down-regulated by Salmonella enterica pathogensa (p-value<0.05). [1]
          hsa-miR-101-3p
             HGF ID HGF0292 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-101-3p expression showed significantly downregulated upon Listeria monocytogenes infection (p-value<0.05). [1]
          hsa-miR-125b-5p
             HGF ID HGF0278 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-125b-5p expression showed significantly upregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-128-3p
             HGF ID HGF0273 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-128 expression showed significantly upregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-146a-5p
             HGF ID HGF0252 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-146 expression and a specific host miRNA response with it takes place during infection with Salmonella enterica. [2]
          hsa-miR-155-5p
             HGF ID HGF0243 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-155 expression and a specific host miRNA response with it takes place during infection with Salmonella enterica. [2]
          hsa-miR-214-3p
             HGF ID HGF0200 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-214 expression showed significantly downregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-29a-3p
             HGF ID HGF0178 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-29a expression showed significantly upregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-29b-3p
             HGF ID HGF0177 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-29a expression showed significantly upregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-30e-5p
             HGF ID HGF0163 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-30e expression showed significantly upregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-331-3p
             HGF ID HGF0157 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-331-3p expression showed significantly upregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-34a-5p
             HGF ID HGF0151 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-34a-5p expression showed significantly downregulated upon Salmonella enterica infection (p-value<0.05). [1]
          hsa-miR-292-5p
             HGF ID HGF2365 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-155 expression showed 2.07-fold up-regulation by Salmonella enterica infection. [3]
Host Immune Factors (HIFs)
          Melanocyte-stimulating hormone alpha
             HIF ID HIFM0064 HIF Info       Class Antimicrobial peptide (AMP)
             Description Salmonella enterica should be able to stimulate production of Alpha-MSH crossreactive auto-Abs. [4]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Immunoblotting with bacterial lysates using sera from Tlr2 / Tlr4 / mice showed reduced IgG in Tlr2 / Tlr4 / sera that recognized antigens produced by fecal bacteria, symbiotic bacteria Eescherichia coli and Klebsiella pneumoniae, as well as the gram-negative enteric pathogens Salmonella enterica serovar Typhimurium (Salmonella) and Citrobacter rodentium. [5]
Environmental Factor(s)
             Disbiome ID
      724
             aBiofilm Organism
      Salmonella enterica
References
1 Multifaceted Roles of microRNAs in Host-Bacterial Pathogen Interaction. Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0002-2019.
2 The intestinal microbiota interferes with the microRNA response upon oral Listeria infection. mBio. 2013 Dec 10;4(6):e00707-13. doi: 10.1128/mBio.00707-13.
3 Whole blood-derived microRNA signatures in mice exposed to lipopolysaccharides. J Biomed Sci. 2012 Jul 31;19(1):69. doi: 10.1186/1423-0127-19-69.
4 Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide -MSH, at the origin of eating disorders.Transl Psychiatry. 2014 Oct 7;4(10):e458. doi: 10.1038/tp.2014.98.
5 Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens.Immunity. 2016 Mar 15;44(3):647-658. doi: 10.1016/j.immuni.2016.02.006. Epub 2016 Mar 2.

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