Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00059)
MIC Name Alcaligenes faecalis (beta-proteobacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Alcaligenaceae
Genus: Alcaligenes
Species: Alcaligenes faecalis
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory
Gram Negative
Genome Size (bp) 4248684
No. of Coding Genes 3752
No. of Non-Coding Genes 67
No. of Small Non-Coding Genes 67
No. of Gene Transcripts 3833
No. of Pseudogenes 14
No. of Base Pairs 4248684
Description Alcaligenes faecalis is an aerobic, Gram negative, rod-shaped bacterium. It was originally named for its first discovery in feces. It is usually a harmless saprophyte in the human intestinal tract. While opportunistic infections do occur, the bacterium is generally considered nonpathogenic. When an opportunistic infection does occur, it is usually observed in the form of a urinary tract infection.
External Links Taxonomy ID
511
Genome Assembly ID
ASM96730v2
GOLD Organism ID
Go0519331
Disease Relevance
          Colon cancer  [ICD-11: 2B90]
             Description The differences at the phylum level between the Ulcerative colitis and Familial adenomatous polyposis cohorts corresponded to significant increases in the levels of the proteobacterial families Comamonadaceae, Moraxellaceae and Alcaligenaceae in tandem with a significant reduction in the Bacteroidetes families Bacteroidaceae and Prevotellaceae and the Firmicutes family Ruminococcaceae in Ulcerative colitis. [1]
          Diabetic foot ulcer  [ICD-11: BD54]
             Description Alcaligenes faecalis was associated with diabetic foot ulcers. [2]
          Otitis media  [ICD-11: AA80]
             Description Alcaligenaceae was associated with chronic suppurative otitis media. [3]
          Urinary tract infection  [ICD-11: GC08]
             Description Alcaligenes faecalis was associated with urinary tract infection. [4]
Host Immune Factors (HIFs)
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description Plasma IgM antibody has reactivity to Sutterella wadsworthensis antigens in autism and gastrointestinal dysfunction patients. [5]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Alcaligenaceae is associated with IgG immune responses. [5]
Environmental Factor(s)
             aBiofilm Organism
      Alcaligenes faecalis
References
1 The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing. Ann Surg. 2010 Jul;252(1):90-8. doi: 10.1097/SLA.0b013e3181e3dc8b.
2 Strain- and Species-Level Variation in the Microbiome of Diabetic Wounds Is Associated with Clinical Outcomes and Therapeutic Efficacy. Cell Host Microbe. 2019 May 8;25(5):641-655.e5. doi: 10.1016/j.chom.2019.03.006. Epub 2019 Apr 18.
3 Three cases of Chronic Suppurative Otitis Media (CSOM) caused by Kerstersia gyiorum and a review of the literature. Infez Med. 2018 Dec 1;26(4):364-368.
4 Clinical evaluation of norfloxacin versus cotrimoxazole in urinary tract infections. Eur J Clin Microbiol. 1983 Jun;2(3):260-5. doi: 10.1007/BF02029529.
5 Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. mBio. 2012 Jan 10;3(1):e00261-11. doi: 10.1128/mBio.00261-11. Print 2012.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.