General Information of MIC (ID: MIC00391)
MIC Name	Enterocloster clostridioformis (firmicutes)
MIC Synonyms	Bacterium clostridiiforme
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Lachnospiraceae Genus: Enterocloster Species: Enterocloster clostridioformis
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Positive
Host Relationship	Pathogen
Description	Enterocloster clostridioformis is a species of anaerobic, Gram positive, rod shaped bacteria assigned to the phylum Firmicutes.
External Links	Taxonomy ID	1531
	Genome Assembly ID	ASM1227319v1
Disease Relevance
Ulcerative colitis  [ICD-11: DD71]
Description	Clostridium clostridioforme was associated with ulcerative colitis.				[1]

Host Genetic Factors (HGFs)
15q11-13
HGF ID	HGF2318	HGF Info	Class	Copy Number Variation: Gene Duplication (CNV-GDu)
Description	There has a significantly different abundance of Clostridium clostridioforme between 15q dup mice and wide type littermates (p-value=0.0382).				[2]
rs1800849
HGF ID	HGF1247	HGF Info	Class	Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
Description	The variant gene UCP3 of innate immunity rs1800849 is significantly associated with the abundance of gut micriobiota Clostridium clostridioforme (p-value=0.0036).				[3]

Host Immune Factors (HIFs)
Neutrophils
HIF ID	HIFC0029	HIF Info	Class	Granulocytes (Gra)
Description	Clostridium clostridioforme at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease.				[4]
CD103+Helios CD4+CD25+FOXP3+ regulatory T cells
HIF ID	HIFC0186	HIF Info	Class	T cells (TCs)
Description	Clostridium clostridioforme is related to the expansion of colonic CD103+HeliosCD4+CD25+FOXP3+ Treg cell population.				[5]

Environmental Factor(s)
Disbiome ID			192

References
1	Correlation of diet, microbiota and metabolite networks in inflammatory bowel disease. J Dig Dis. 2019 Sep;20(9):447-459. doi: 10.1111/1751-2980.12795. Epub 2019 Aug 1.
2	Altered microbiota composition reflects enhanced communication in 15q11-13 CNV mice.Neurosci Res. 2019 Dec 18:S0168-0102(19)30671-6. doi: 10.1016/j.neures.2019.12.010. Online ahead of print.
3	Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
4	Stool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation.Clin Infect Dis. 2017 Nov 29;65(12):1984-1991. doi: 10.1093/cid/cix699.
5	Development and maintenance of intestinal regulatory T cells.Nat Rev Immunol. 2016 May;16(5):295-309. doi: 10.1038/nri.2016.36. Epub 2016 Apr 18.

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