Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01125)
MIC Name Rothia mucilaginosa (actinobacteria)
MIC Synonyms Micrococcus mucilaginosus
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Micrococcales
Family: Micrococcaceae
Genus: Rothia
Species: Rothia mucilaginosa
Oxygen Sensitivity Microaerophile
Microbial Metabolism Fermentative
Gram Positive
Host Relationship Opportunistic pathogen
Genome Size (bp) 2292716
No. of Coding Genes 1762
No. of Non-Coding Genes 57
No. of Small Non-Coding Genes 57
No. of Gene Transcripts 1819
No. of Base Pairs 2292716
Description Rothia mucilaginosa is a microaerophilc, Gram-positive coccus member of the family Micrococcaceae. It is considered part of the normal microflora of the human mouth and the upper respiratory tract. Although this organism is believed to be of low virulence, it is increasingly recognized as an opportunistic pathogen mostly affecting immunocompromised hosts. It is increasingly recognized as an emerging opportunistic pathogen associated with prosthetic device infections. Infective endocarditis is one of the most common clinical presentations.
External Links Taxonomy ID
43675
Genome Assembly ID
ASM154823v1
GOLD Organism ID
Go0004487
Disease Relevance
          Autoimmune liver disease  [ICD-11: DB96]
             Description Rothia mucilaginosa is upregulated in disease expression of primary sclerosing cholangitis. [1]
          Infectious endocarditis  [ICD-11: BB40]
             Description Rothia mucilaginosa is increasingly recognized as an emerging opportunistic pathogen associated with prosthetic device infections. Infective endocarditis is one of the most common clinical presentations. [2]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Rothia mucilaginosa is upregulated in inflammatory bowel disease. [1]
          Meningococcal disease  [ICD-11: 1C1C]
             Description Rothia mucilaginosa was associated with bacteremia. [3]
          Ulcerative colitis  [ICD-11: DD71]
             Description Rothia mucilaginosa was associated with ulcerative colitis. [1]
Host Genetic Factors (HGFs)
          rs1894798
             HGF ID HGF2234 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1894798 SNP was significantly associated with the abundance of Mucilaginosa (p-value<1.00E-08). [4]
          rs2641348
             HGF ID HGF2647 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-MV)
             Description The rs2641348 SNP is associated with the abundance of Rothia mucilaginosa. [5]
          rs2024092
             HGF ID HGF2554 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2024092 SNP is associated with the abundance of Rothia mucilaginosa. [5]
          rs1517352
             HGF ID HGF2547 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1517352 SNP is associated with the abundance of Rothia mucilaginosa. [5]
          rs2457996
             HGF ID HGF2540 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2457996 SNP is associated with the abundance of Rothia mucilaginosa. [5]
          rs6651252
             HGF ID HGF2561 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6651252 SNP is associated with the abundance of Rothia mucilaginosa. [5]
          rs568617
             HGF ID HGF2648 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs568617 SNP is associated with the abundance of Rothia mucilaginosa. [5]
          rs7746082
             HGF ID HGF2649 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7746082 SNP is associated with the abundance of Rothia mucilaginosa. [5]
          rs561722
             HGF ID HGF2632 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs561722 SNP is associated with the abundance of Rothia mucilaginosa. [5]
Host Immune Factors (HIFs)
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Rothia mucilaginosa at neutrophil recovery was positively correlated with subsequent acute severe graft-versus-host disease. [6]
Environmental Factor(s)
             Disbiome ID
      402
             gutMDisorder ID
      gm0578
References
1 Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
2 Rothia mucilaginosa prosthetic device infections: a case of prosthetic valve endocarditis. J Clin Microbiol. 2013 May;51(5):1629-32. doi: 10.1128/JCM.03173-12. Epub 2013 Mar 6.
3 Rothia bacteremia: a 10-year experience at Mayo Clinic, Rochester, Minnesota. J Clin Microbiol. 2014 Sep;52(9):3184-9. doi: 10.1128/JCM.01270-14. Epub 2014 Jun 20.
4 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
5 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
6 Stool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation.Clin Infect Dis. 2017 Nov 29;65(12):1984-1991. doi: 10.1093/cid/cix699.

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